Recombinant Human TNFRSF6B, Fc Chimera

• Cat.No.: TNFRSF6B-2078H
• Product Overview: Recombinant Human TNFRSF6B is produced inHEK 293 Cells.The extracellular domain of human DcR3 (decoy receptor 3) (aa 1-246) is fused to the Fc portion of human IgG1. MW=58kDa.

Specification

• Species: Human
• Source: HEK293
• Tag: Fc
• Protein Length: 1-246 a.a.
• Description: This gene belongs to the tumor necrosis factor receptor superfamily. The encoded protein is postulated to play a regulatory role in suppressing FasL- and LIGHT-mediated cell death. It acts as a decoy receptor that competes with death receptors for ligand binding. Overexpression of this gene has been noted in gastrointestinal tract tumors, and it is located in a gene-rich cluster on chromosome 20, with other potentially tumor-related genes. Two transcript variants encoding the same isoform, but differing in the 5" UTR, have been observed for this gene.
• Concentration: 1mg/ml after reconstitution.
• Formulation: Lyophilized. Contains PBS.
• Endotoxin Content: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
• Reconstitution: Reconstitute with 50µl sterile water.
• Specificity: Binds human LIGHT. Does not bind human FasL.
• Application: Detection of human LIGHT and TL1A (VEGI) in combination with PAb to human IgG1.
• Purity: ≥90% (SDS-PAGE).
• Storage: Stable for at least 6 months after receipt when stored at -20°C. Avoid freeze/thaw cycles.

Gene Information

• Gene Name: TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy [ Homo sapiens ]
• Synonyms: TNFRSF6B; tumor necrosis factor receptor superfamily, member 6b, decoy; M68; TR6; DCR3; DJ583P15.1.1; TNFRSF6B; tumor necrosis factor receptor superfamily member 6B; decoy receptor 3; decoy receptor for Fas ligand
• Gene ID: 8771
• mRNA Refseq: NM_003823
• Protein Refseq: NP_003814
• MIM: 603361
• UniProt ID: O95407
• Chromosome Location: 20q13.3
• Pathway: Cytokine-cytokine receptor interaction
• Function: protein binding; receptor activity