Recombinant Human TLR1, Fc Chimera

• Cat.No.: TLR1-685H
• Product Overview: Recombinant Human TLR1 isproduced in mouseNSO/1 cells. The extracellular domain of human TLR1 is fused to the Fc portion of human IgG1. MW=120kDa (SDS-PAGE).

Specification

• Species: Human
• Source: Mammalian Cells
• Tag: Fc
• Description: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity.
• Purity: ≥95% (SDS-PAGE).
• Endotoxin Content: <0.1EU/µg purified protein (LAL test; Bio Whittaker).
• Concentration: 1mg/ml after reconstitution.
• Formulation: Lyophilized. Contains PBS.
• Reconstitution: Reconstitute with 50µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
• Stability: Stable for at least 6 months after receipt when stored at -20°C.
• Storage: Long term storage: -20°C, short term storage: +4°C. After reconstitution, prepare aliquots and store at -20°C. Avoid freeze/thaw cycles.

Gene Information

• Gene Name: TLR1 toll-like receptor 1 [ Homo sapiens ]
• Synonyms:
  TLR1; toll-like receptor 1; TIL; CD281; rsc786; KIAA0012; MGC104956; MGC126311; MGC126312; TIL. LPRS5; DKFZp547I0610; DKFZp564I0682
• Gene ID: 7096
• mRNA Refseq: NM_003263
• Protein Refseq: NP_003254
• MIM: 601194
• UniProt ID: Q15399
• Chromosome Location: 4p14
• Pathway: Toll-like receptor signaling pathway; Signaling in Immune system
• Function: protein binding; receptor activity; transmembrane receptor activity