Active Recombinant Human TLR1, Fc-tagged

• Cat.No.: TLR1-706H
• Product Overview: The recombinant human TLR1-Fc fusion protein is expressed as a 778 amino acid protein consisting of Ser25 - Glu574 region of TLR1 (UniProt accession #Q15399) and a C-terminal Fc from human IgG1, which exists as a dimer under non-reducing conditions.

Specification

• Species: Human
• Source: Human Cells
• Tag: Fc
• Protein Length: 25-574 a.a.
• Form: Supplied at 0.5 mg/ml in sterile PBS pH7.4 (carrier & preservative free).
• Bio-activity: Binds to the triacylated peptide biotinylated Pam3CysSerLys4 (PAM3CSK4).
• Molecular Mass: Calculated molecular mass (kDa): 88.1; Estimated by SDS-PAGE under reducing condition (kDa): 90-100
• Endotoxin: <0.1 eu="" per="" 1="" μg="" of="" purified="" recombinant="" protein="" determined="" by="" the="" lal="">
• Purity: >90% judged by SDS-PAGE under reducing condition
• Storage: The product is shipped at 4°C. Upon receipt, centrifuge the product briefly before opening the vial. It is recommended to store small aliquots at the temperature below –20°C for long-term storage and the product is stable for 3 months. The undiluted protein can be stored at 4°C for no more than 2 weeks. Avoid repeated freeze-thaw cycles.

Gene Information

• Gene Name: TLR1 toll-like receptor 1 [ Homo sapiens ]
• Official Symbol: TLR1
• Synonyms: TLR1; toll-like receptor 1; CD281; KIAA0012; rsc786; toll/interleukin-1 receptor-like protein; TIL; TIL. LPRS5; MGC104956; MGC126311; MGC126312; DKFZp547I0610; DKFZp564I0682
• Gene ID: 7096
• mRNA Refseq: NM_003263
• Protein Refseq: NP_003254
• MIM: 601194
• UniProt ID: Q15399
• Chromosome Location: 4p14
• Pathway: Activated TLR4 signalling, organism-specific biosystem; Beta defensins, organism-specific biosystem; Defensins, organism-specific biosystem; Immune System, organism-specific biosystem; Innate Immune System, organism-specific biosystem; MyD88:Mal cascade initiated on plasma membrane, organism-specific biosystem; Toll Like Receptor 2 (TLR2) Cascade, organism-specific biosystem
• Function: lipopeptide binding; protein heterodimerization activity; receptor activity; transmembrane signaling receptor activity