TLR1
-
Official Full Name
toll-like receptor 1 -
Overview
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is ubiquitously expressed, and at higher levels than other TLR genes. Different length transcripts presumably resulting from use of alternative polyadenylation site, and/or from alternative splicing, have been noted for this gene. -
Synonyms
TLR1;toll-like receptor 1;TIL;CD281;rsc786;KIAA0012;MGC104956;MGC126311;MGC126312;TIL. LPRS5;DKFZp547I0610;DKFZp564I0682;OTTHUMP00000218158;OTTHUMP00000218173;OTTHUMP00000218175;toll/interleukin-1 receptor-like protein;Similar to Drosophila Toll protein;Toll (Drosophila) homolog;Toll like receptor 1;Toll like receptor 1 Precursor;Toll/Interleukin 1 receptor like
Recombinant Proteins
- Human
- Rhesus macaque
- Mouse
- Zebrafish
- E.coli
- Mammalian Cells
- Human Cells
- HEK293
- Yeast
- GST
- Fc
- Non
- hIgG4
- His&S
- His&GST
- His
- His&Fc&Avi
Involved Pathway
TLR1 involved in several pathways and played different roles in them. We selected most pathways TLR1 participated on our site, such as Toll-like receptor signaling pathway,Tuberculosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with TLR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Toll-like receptor signaling pathway | IFNA12,MAP3K7,IFNA14,MAP2K3,STAT1,PIK3CB,RAC1A,IL-8,MAP2K2B,IKBKB |
| Tuberculosis | RELA,FCGR4,MAPK8,HLA-DPA1,FCGR3,Ifna11,Itgam&Itgb2,CASP8,CEBPG,PMAP-36 |
Protein Function
TLR1 has several biochemical functions, for example, Toll-like receptor 2 binding,protein binding,protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by TLR1 itself. We selected most functions TLR1 had, and list some proteins which have the same functions with TLR1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transmembrane signaling receptor activity | CD5,EVI2A,KLRC3,CD72,P2RX5,TLR7,FZD3B,LGR4,OR4D2,OR12D3 |
| protein heterodimerization activity | APOA2,Fzd4,CUL5,KCNA3,UGT1A2,SMAD3,HEYL,PDSS2,PVRL1,KCNIP1 |
| Toll-like receptor 2 binding | TIRAP,TLR6 |
| receptor activity | NR2C1,PVRL3B,CXCR3,CADM3,KIR2DL1,PAQR5B,GP6,MED30,SEC63,STRA6 |
| protein binding | HIST1H2AI,CCDC22,PIAS1,SOAT1,TDGF1,COL6A2,NIPA2,MTMR14,TBL3,FUS |
Interacting Protein
TLR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with TLR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of TLR1.
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Resources
Research Area
NeuroinflammationImmune Regulatory Molecules on Endothelial Cells
T Cell Antigen Recognition
Other Dendritic Cell CD Antigen
CD Antigen (Neutrophils)
Monocyte Marker CD Antigen
Other Monocytes/Macrophages CD Antigen
NOD-like Receptors and the Inflammasome
Toll-Like Receptors (TLRs)
Related Services
Related Products
References
- Ammerdorffer, A; Schoffelen, T; et al. Recognition of Coxiella burnetii by Toll-like Receptors and Nucleotide-Binding Oligomerization Domain-like Receptors. JOURNAL OF INFECTIOUS DISEASES 211:978-987(2015).
- Zhang, XJ; Xu, J; et al. Expression and function of Toll-like receptors in peripheral blood mononuclear cells from patients with ovarian cancer. CANCER IMMUNOLOGY IMMUNOTHERAPY 64:275-286(2015).
