Recombinant Human TEAD2 Protein, His-tagged

• Cat.No.: TEAD2-08H
• Product Overview: Human TEAD2 (aa217-447), with C-terminal His-tag, was expressed from E.coli and purified by a three-step chromatographic procedure comprising affinity, ion exchange and gel filtration chromatography steps.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 217-447 a.a.
• Description: Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.
• Molecular Mass: 29.7 kDa
• Purity: >95%
• Storage Buffer: 20 mM TRIS/HCl pH 8.0, 100 mM NaCl, 2 mM MgCl2, 1 mM TCEP, 5% glycerol

Gene Information

• Gene Name: TEAD2 TEA domain transcription factor 2 [ Homo sapiens (human) ]
• Official Symbol: TEAD2
• Synonyms: TEAD2; TEA domain transcription factor 2; ETF; TEF4; TEF-4; TEAD-2; transcriptional enhancer factor TEF-4; TEA domain family member 2
• Gene ID: 8463
• mRNA Refseq: NM_001256658
• Protein Refseq: NP_001243587
• MIM: 601729
• UniProt ID: Q15562