Recombinant Human STC2, FLAG-tagged

• Cat.No.: STC2-30114TH
• Product Overview: Recombinant full length mature protein, corresponding to amino acids 25-302 of Human Stanniocalcin 2, expressed in HEK cells with a C-TerminalAA ADYKDDDDK-tag.

Specification

• Species: Human
• Tag: Flag
• Protein Length: 25-302 a.a.
• Description: This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers.
• Conjugation: FLAG
• Tissue specificity: Expressed in a variety of tissues including muscle, heart, pancreas, kidney, spleen, prostate, small intestine, colon and peripheral blood leukocytes.
• Form: Lyophilised:Add deionized water to prepare a working stock solution of approximately 0.5 mg/mL and let the lyophilized pellet dissolve completely.
• Purity: >90% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 20mM Sodium chloride, 20mM Tris, pH 7.5
• Storage: Aliquot and store at -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: TDATNPPEGP QDRSSQQKGR LSLQNTAEIQ HCLVNAGDVGCGVFECFENN SCEIRGLHGI CMTFLHNAGK FDAQGKSFIKDALKCKAHAL RHRFGCISRK CPAIREMVSQ LQRECYLKHDLCAAAQENTR VIVEMIHFKD LLLHEPYVDL VNLLLTCGEEVKEAITHSVQ VQCEQNWGSL CSILSFCTSA IQKPPTAPPERQPQVDRTKL SRAHHGEAGH HLPEPSSRET GRGAKGERGSKSHPNAHARG RVGGLGAQGP SGSSEWEDEQ SEYSDIRR-AA ADYKDDDDK
• Sequence Similarities: Belongs to the stanniocalcin family.
• Full Length: Full L.

Gene Information

• Gene Name: STC2 stanniocalcin 2 [ Homo sapiens ]
• Official Symbol: STC2
• Synonyms: STC2; stanniocalcin 2; stanniocalcin-2; STC 2
• Gene ID: 8614
• mRNA Refseq: NM_003714
• Protein Refseq: NP_003705
• MIM: 603665
• Uniprot ID: O76061
• Chromosome Location: 5q35.2
• Function: hormone activity