STC2
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Official Full Name
stanniocalcin 2 -
Overview
This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The encoded protein has 10 of its 15 cysteine residues conserved among stanniocalcin family members and is phosphorylated by casein kinase 2 exclusively on its serine residues. Its C-terminus contains a cluster of histidine residues which may interact with metal ions. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Constitutive overexpression of human stanniocalcin 2 in mice resulted in pre- and postnatal growth restriction, reduced bone and skeletal muscle growth, and organomegaly. Expression of this gene is induced by estrogen and altered in some breast cancers. -
Synonyms
STC2;stanniocalcin 2;stanniocalcin-2;STC 2;STC-related protein;stanniocalcin-related protein;STC-2;STCRP
Recombinant Proteins
- Mouse
- Human
- Rat
- HEK293
- E.coli
- Human Cells
- Mammalian Cells
- His
- Flag
- Fc&His
- T7
- Flag&His
- Non
- Fc
- DDK&Myc
- GST
- Avi&Fc&His
Involved Pathway
STC2 involved in several pathways and played different roles in them. We selected most pathways STC2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with STC2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
STC2 has several biochemical functions, for example, enzyme binding,heme binding,hormone activity. Some of the functions are cooperated with other proteins, some of the functions could acted by STC2 itself. We selected most functions STC2 had, and list some proteins which have the same functions with STC2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| enzyme binding | SPDL1,UGT1A2,HIF1A,HINFP,PHB,LDB2,LAMP1,ANK1,NFKBIA,RCOR3 |
| hormone activity | PRL7B1,GCG,PRL2C2,SST3,GNRH3,AGT,INSB,IAPP,IGF2,GNRH2 |
| protein homodimerization activity | PDGFB,HSP90AA1,CITED1,CTBP2A,GPD1A,ACTN1,CD226,GPD1,PLDN,TGFB1 |
| heme binding | CYP1D1,CYP27C1,NOS3,HEBP1,DUOX2,CYP2E1,CYP2S1,HBB-B2,CYP2AA3,CYP2AD3 |
Interacting Protein
STC2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STC2 here. Most of them are supplied by our site. Hope this information will be useful for your research of STC2.
ADAM11;AIFM1;POLR2C;PTN;PEBP1;ARRB2;PPP1R8;ARHGEF40;POLR3F;EIF2B3;CARHSP1
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References
- Miyazaki, S; Kikuchi, H; et al. Anti-VEGF antibody therapy induces tumor hypoxia and stanniocalcin 2 expression and potentiates growth of human colon cancer xenografts. INTERNATIONAL JOURNAL OF CANCER 135:295-307(2014).
- Kashyap, MK; Pawar, HA; et al. Evaluation of protein expression pattern of stanniocalcin 2, insulin-like growth factor-binding protein 7, inhibin beta A and four and a half LIM domains 1 in esophageal squamous cell carcinoma. CANCER BIOMARKERS 12:1-9(2012).
