Recombinant Human STAT4, His-tagged

• Cat.No.: STAT4-30117TH
• Product Overview: Recombinant full length Human STAT4 with N terminal His tag, expressed in a Baculovirus infected Sf9 cell expression system, amino acids 1-748, MW 87kDa.

Specification

• Description: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein.
• Conjugation: HIS
• Form: Liquid
• Storage buffer: Preservative: 150mM ImidazoleConstituents: 25% Glycerol, 0.1% PMSF, 50mM Sodium phosphate, 300mM Sodium chloride, 0.2mM DTT, pH 7
• Storage: Shipped on dry ice. Upon delivery aliquot and store at -80oC. Avoid freeze / thaw cycles.
• Sequence Similarities: Belongs to the transcription factor STAT family.Contains 1 SH2 domain.
• Protein length: 1-748 a.a.
• Full Length: Full L.

Gene Information

• Gene Name: STAT4 signal transducer and activator of transcription 4 [ Homo sapiens ]
• Official Symbol: STAT4
• Synonyms: STAT4; signal transducer and activator of transcription 4
• Gene ID: 6775
• mRNA Refseq: NM_001243835
• Protein Refseq: NP_001230764
• MIM: 600558
• Uniprot ID: Q14765
• Chromosome Location: 2q32.2-q32.3
• Pathway: Downstream signaling in naive CD8+ T cells, organism-specific biosystem; IL12 signaling mediated by STAT4, organism-specific biosystem; IL12-mediated signaling events, organism-specific biosystem; IL23-mediated signaling events, organism-specific biosystem; IL27-mediated signaling events, organism-specific biosystem
• Function: calcium ion binding; sequence-specific DNA binding; sequence-specific DNA binding transcription factor activity; signal transducer activity