Recombinant Human Signal Transducer And Activator Of Transcription 4, His-tagged

• Cat.No.: STAT4-4888H
• Product Overview: Recombinant full-length human STAT4 was expressed by baculovirus in Sf9 insect cells using an N-terminal His tag.

Specification

• Cat. No.: STAT4-4888H
• Description: STAT4 (signal transducer and activator of transcription 4) is a member of the STAT family that is phosphorylated by receptor-associated protein kinases. STATs form homo- or heterodimers and translocate to the cell nucleus where they act as transcription activators. T helper (Th) cells differentiation is regulated by STAT4. STAT4 controls T1/T2 balance during the response to live influenza virus and isolated viral proteins. The differentiation of gamma interferon (IFN-γ)-producing Th1 and Tc1 cells after inoculation of live virus occurred independently of STAT4 expression. STAT4 has been shown to control pathogenesis of chronic obstructive pulmonary disease.
• Applications: Kinase Assay; Western Blot
• Molecular Weight: 87 kDa
• Expression System: Sf9 insect cells using baculovirus
• Species: Human
• Form: Recombinant protein stored in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150 mM imidazole, 0.1 mM PMSF, 0.25 mM DTT, 25% glycerol.
• Purity: > 95 %
• Concentration: 0.2 ug/ul
• Sequences: Full-length
• Storage: Store product at -70oC. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles.
• Pathways: Jak-STAT signaling pathway

Gene Information

• Gene Name: STAT4 signal transducer and activator of transcription 4 [ Homo sapiens ]
• Official Symbol: STAT4
• Synonyms: STAT4; signal transducer and activator of transcription 4; SLEB11; OTTHUMP00000163553
• Gene ID: 6775
• mRNA Refseq: NM_003151
• Protein Refseq: NP_003142
• MIM: 600558
• UniProt ID: Q14765
• Chromosome Location: 2q32.2-q32.3
• Function: calcium ion binding; protein binding; signal transducer activity; transcription factor activity