Recombinant Human SP100 nuclear antigen Protein, His&Flag&StrepII tagged

• Cat.No.: SP100-105H
• Product Overview: Recombinant human SP100 protein (Q9HB58) (Glu 350-Lys 530) with a Twin strep tag at the N-terminus and both His, Flag tag at the C-terminus was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: Flag&His&Twin Strep
• Protein Length: 350-530aa
• Description: The nuclear body is a multiprotein complex that may have a role in the regulation of gene transcription. This gene is a member of the SP100/SP140 family of nuclear body proteins and encodes a leukocyte-specific nuclear body component. The protein can function as an activator of gene transcription and may serve as a nuclear hormone receptor coactivator. In addition, it has been suggested that the protein may play a role in ribosome biogenesis and in the induction of myeloid cell differentiation. Alternative splicing has been observed for this gene and three transcript variants, encoding distinct isoforms, have been identified. Transcription factor. May be a nuclear hormone receptor coactivator. Enhances transcription of genes with retinoic acid response elements.
• Tag: N-Twin strep and C-His&Flag
• Molecular Mass: 27.3 kDa
• Endotoxin: Less than 1.0 EU/μg by the LAL method.
• Purity: >95% as determined by SDS-PAGE.
• Storage: Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade. It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.
• Reconstitution: Reconstitute at 250 μg/mL in sterile water.

Gene Information

• Gene Name: SP100 SP100 nuclear antigen [ Homo sapiens (human) ]
• Official Symbol: SP100
• Synonyms: SP100; SP100 nuclear antigen; nuclear antigen Sp100; nuclear autoantigen Sp-100; speckled 100 kDa; SP100-HMG nuclear autoantigen; nuclear dot-associated Sp100 protein; lysp100b; FLJ00340; FLJ34579; DKFZp686E07254
• Gene ID: 6672
• mRNA Refseq: NM_001080391
• Protein Refseq: NP_001073860
• MIM: 604585
• UniProt ID: P23497