Recombinant Human SMAD6 cell lysate

• Cat.No.: SMAD6-1644HCL

Specification

• Description: The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila mothers against decapentaplegic (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants encoding different isoforms have been found for this gene
• Species: Human
• Size: 100 ul
• Storage Buffer: 1X Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, 0.01% Bromophenol blue)
• Applications: Western Blot
• Tag: Non

Gene Information

• Gene Name: SMAD6 SMAD family member 6 [ Homo sapiens ]
• Official Symbol: SMAD6
• Synonyms: SMAD6; SMAD family member 6; MAD, mothers against decapentaplegic homolog 6 (Drosophila) , MADH6, MADH7, SMAD, mothers against DPP homolog 6 (Drosophila); mothers against decapentaplegic homolog 6; HsT17432; SMAD 6; hSMAD6; MAD homolog 6; mothers against DPP homolog 6; SMAD, mothers against DPP homolog 6; Mothers against decapentaplegic, drosophila, homolog of, 6; MADH6; MADH7
• Gene ID: 4091
• mRNA Refseq: NM_001142861
• Protein Refseq: NP_001136333
• MIM: 602931
• UniProt ID: O43541
• Chromosome Location: 15q21-q22
• Pathway: BMP receptor signaling, organism-specific biosystem; Endocytosis, organism-specific biosystem; Endocytosis, conserved biosystem; Signal Transduction, organism-specific biosystem; Signaling by BMP, organism-specific biosystem; Signaling by TGF beta, organism-specific biosystem; TGF Beta Signaling Pathway, organism-specific biosystem
• Function: I-SMAD binding; R-SMAD binding; chromatin binding; co-SMAD binding; protein binding; sequence-specific DNA binding transcription factor activity; transcription regulatory region DNA binding; transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity; transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity; type I activin receptor binding; type I transforming growth factor beta receptor binding; ubiquitin protein ligase binding