SMAD6
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Official Full Name
SMAD family member 6 -
Overview
The protein encoded by this gene belongs to the SMAD family of proteins, which are related to Drosophila mothers against decapentaplegic (Mad) and C. elegans Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions in the negative regulation of BMP and TGF-beta/activin-signalling. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2009] -
Synonyms
SMAD6;SMAD family member 6;AOVD2;MADH6;MADH7;HsT17432;mothers against decapentaplegic homolog 6;SMAD 6;hSMAD6;MAD homolog 6;mothers against DPP homolog 6;SMAD, mothers against DPP homolog 6;Mothers against decapentaplegic, drosophila, homolog of, 6
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Chicken
- Rat
- E.coli
- Mammalian Cell
- HEK293
- Insect Cell
- Wheat Germ
- HEK293T
- In Vitro Cell Free System
- His
- Non
- Myc&DDK
- His&Myc
- GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SMAD6-2801H | Recombinant Human SMAD6, His-tagged | E.coli | Human | His | 1-496aa | |
| SMAD6-15589M | Recombinant Mouse SMAD6 Protein | Mammalian Cell | Mouse | His |
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| SMAD6-4113Z | Recombinant Zebrafish SMAD6 | Mammalian Cell | Zebrafish | His |
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| SMAD6-5821C | Recombinant Chicken SMAD6 | Mammalian Cell | Chicken | His |
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| SMAD6-1644HCL | Recombinant Human SMAD6 cell lysate | Human | Non |
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| PGC-299H | Recombinant Human SMAD6 Protein, His-tagged | E.coli | Human | His | Cys261~Pro495 |
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| SMAD6-1913H | Recombinant Human SMAD6 Protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| SMAD6-2257H | Recombinant Human SMAD6 protein, His&Myc-tagged | Insect Cell | Human | His&Myc | 1-496aa |
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| SMAD6-22H | Recombinant Human SMAD6 Protein, GST-tagged | Wheat Germ | Human | GST |
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| Smad6-300M | Recombinant Mouse Smad6 Protein, His-tagged | E.coli | Mouse | His | Pro116~Gly364 |
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| Smad6-301R | Recombinant Rat Smad6 Protein, His-tagged | E.coli | Rat | His | Gln171~Asp441 |
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| SMAD6-3507H | Recombinant Human SMAD6 protein, His&Myc-tagged | E.coli | Human | His&Myc | 1-496aa |
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| SMAD6-5065H | Recombinant Human SMAD6 protein, His&Myc-tagged | HEK293 | Human | His&Myc | 1-496aa |
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| Smad6-5953M | Recombinant Mouse Smad6 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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| SMAD6-6773HF | Recombinant Full Length Human SMAD6 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 496 amino acids |
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| SMAD6-8458M | Recombinant Mouse SMAD6 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SMAD6-8458M-B | Recombinant Mouse SMAD6 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
SMAD6 involved in several pathways and played different roles in them. We selected most pathways SMAD6 participated on our site, such as TGF-beta signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with SMAD6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| TGF-beta signaling pathway | BMP7,BAMBIA,SMAD3A,TGFB2,TFDP1,ACVR2B,BMP7B,CHD,RHOAC,BMPR1B |
Protein Function
SMAD6 has several biochemical functions, for example, I-SMAD binding,R-SMAD binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SMAD6 itself. We selected most functions SMAD6 had, and list some proteins which have the same functions with SMAD6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| R-SMAD binding | SMAD4,ZC3H3,FOXH1,AXIN1,PMEPA1,MEN1,MYOCD,SMAD2,PARP1,PAX6 |
| identical protein binding | CEP170L,KIRRELA,SDF4,EGFR,ESYT2,VEGFA,KCTD17,AHCY,USP15,S100A2 |
| ubiquitin protein ligase binding | TMEM189,CHEK2,AURKA,PARK2,TMEM173,RNF20,GPI,RNF31,ERLIN2,POLR2A |
| transcription factor activity, sequence-specific DNA binding | HOXC6,VDRA,NPAS2,E4F1,ARNT2,ELK3,HOMEZA,ATF4,ZNF501,ZSCAN10 |
| transcription regulatory region DNA binding | JUN,IKZF4,ARID5A,ZFP821,TFAP2A,ZNF613,TRP63,HOXA13,TP73,TA |
| chromatin binding | EBF2,SSRP1,LOXL2,PHF21B,TFAM,PRKAA2,TCF7,PCGF2,TFAP2A,HESX1 |
| protein binding | DDX31,TGM2,PRDM4,TIMP3,NXF3,LSM4,YWHAQ,HPS1,AICDA,ZFP161 |
| metal ion binding | ZNFL1,BA1,ZNF133,GMPR2,CYP2C38,BMPR1A,ZNF232,CXXC1B,ZNF530,ZBTB8A |
| co-SMAD binding | SMAD1,TRIM33,SMAD2,USP9X,SMAD3,GATA4,TGIF1,CITED1,FOXH1 |
Interacting Protein
SMAD6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SMAD6 here. Most of them are supplied by our site. Hope this information will be useful for your research of SMAD6.
PRKX;SMAD1;Runx2;RUNX2;UBE2O;RPS6KA5;FKBP1A;MAPK6;SMURF2
SMAD6 Related Signal Pathway
Resources
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References
- Islam, SS; Mokhtari, RB; et al. Spatio-Temporal Distribution of Smads and Role of Smads/TGF-beta/BMP-4 in the Regulation of Mouse Bladder Organogenesis. PLOS ONE 8:-(2013).
- Kaneda, A; Fujita, T; et al. Activation of Bmp2-Smad1 Signal and Its Regulation by Coordinated Alteration of H3K27 Trimethylation in Ras-Induced Senescence. PLOS GENETICS 7:-(2011).
