Recombinant Human SIRT1 protein, His-tagged

• Cat.No.: SIRT1-4642H
• Product Overview: Recombinant Human SIRT1 protein(Q96EB6)(2-747aa), fused to N-terminal His tag, was expressed in E. coli

Specification

• Source: E. coli
• Species: Human
• Tag: His
• Form: If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
  If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
• Molecular Mass: 85.5 kDa
• Protein length: 2-747aa
• Purity: Greater than 90% as determined by SDS-PAGE.
• Storage: Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
• Reconstitution: Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%.

Gene Information

• Gene Name: SIRT1 sirtuin 1 [ Homo sapiens ]
• Official Symbol: SIRT1
• Synonyms: SIRT1; sirtuin 1; sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) , sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 1; NAD-dependent deacetylase sirtuin-1; SIR2L1; hSIR2; hSIRT1; SIR2alpha; sir2-like 1; sirtuin type 1; SIR2-like protein 1
• Gene ID: 23411
• mRNA Refseq: NM_001142498
• Protein Refseq: NP_001135970
• MIM: 604479
• UniProt ID: Q96EB6

Reviews

10/12/2021

Resulting banding is clear and bright, much more than expected.

10/09/2021

SIRT1 has high safety, environmental protection and no pollution.

01/03/2021

The quality is so good. It saves a lot of time. Good.

Q&As

Does SIRT1 play a role in tissue regeneration?

Studies have found that SIRT1 plays an important role in tissue regeneration. Activation of SIRT1 can promote the proliferation and differentiation of stem cells, which contributes to tissue regeneration and repair.

Is SIRT1 related to autophagy?

Activation of SIRT1 promotes autophagy, which helps to remove damaged organelles and proteins and maintain cell health.

What is the relationship between SIRT1 and mitochondrial function?

SIRT1 regulates mitochondrial function. Activation of SIRT1 can improve mitochondrial metabolism and function, contributing to energy metabolism and cell survival.

What role does SIRT1 play in cancer?

Studies have found that SIRT1 exerts carcinogenic effects in some cancers, but exerts anti-cancer effects in others. It depends on the type of cancer and environmental factors.

What is the potential of SIRT1 in drug development?

SIRT1 has potential therapeutic value in drug development. The development of small molecule drugs targeting SIRT1 can be used to treat a variety of diseases, including aging, diabetes, cardiovascular diseases, and neurodegenerative diseases.

How does SIRT1 relate to other sirtuins?

SIRT1 interacts and regulates with other sirtuins. For example, SIRT1 can regulate the expression and activity of other Sirtuins, and other Sirtuins can also regulate the activity of SIRT1.