Recombinant Human SIRT1, His-tagged

Description :	This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.
Protein length :	554 amino acids
Conjugation :	HIS
Molecular Weight :	70.000kDa
Source :	E. coli
Tissue specificity :	Widely expressed.
Biological activity :	HDAC activity.
Form :	Liquid
Purity :	>95% by SDS-PAGE
Storage buffer :	Preservative: NoneConstituents: 55mM Tris HCl, 150mM Sodium chloride, pH 8.2
Storage :	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Sequence Similarities :	Belongs to the sirtuin family.Contains 1 deacetylase sirtuin-type domain.

Gene Name	SIRT1 sirtuin 1 [ Homo sapiens ]
Official Symbol	SIRT1
Synonyms	SIRT1; sirtuin 1; sirtuin (silent mating type information regulation 2 homolog) 1 (S. cerevisiae) , sirtuin (silent mating type information regulation 2, S. cerevisiae, homolog) 1; NAD-dependent deacetylase sirtuin-1; SIR2L1;
Gene ID	23411
mRNA Refseq	NM_001142498
Protein Refseq	NP_001135970
MIM	604479
Uniprot ID	Q96EB6
Chromosome Location	10q21
Pathway	E2F transcription factor network, organism-specific biosystem; Energy Metabolism, organism-specific biosystem; FoxO family signaling, organism-specific biosystem; HIF-2-alpha transcription factor network, organism-specific biosystem; Regulation of Androgen receptor activity, organism-specific biosystem;
Function	HLH domain binding; NOT NAD+ ADP-ribosyltransferase activity; NAD+ binding; NAD-dependent histone deacetylase activity; NAD-dependent histone deacetylase activity (H3-K9 specific);