Recombinant Human SCO2

• Cat.No.: Sco2-170H
• Product Overview: RecombinantHuman Sco2 was cloned from Human cDNA and expressed inE.coli. The protein consists of the soluble domain (aa 100-266) of the apo-HSco2SH, which lacks the transmembrane segment (NCBI accession NP_005129). Four additional aa (GSFT) are present at the N-term end of the protein. MW = 19.5 kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Protein Length: 100-266 a.a.
• Description: Protein SCO2 homolog, mitochondrial is a protein that in humans is encoded by the SCO2 gene. Mammalian cytochrome c oxidase (COX) catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. In yeast, 2 related COX assembly genes, SCO1 and SCO2 (synthesis of cytochrome c oxidase), enable subunits 1 and 2 to be incorporated into the holoprotein. This gene is the human homolog of the yeast SCO2 gene.
• Purity: >95% by SDS-PAGE. The protein was observed as a single band migrating at a molecular weight of >18kDa.
• Supplied As: 1.0mg at 1.0mg/ml in 50Mm KH2PO4/K2HPO4, pH7.2, 1mM Dithiothreitol. The concentration is calculated from the absorbance at 280nm (e280nm =19035M^-1cm^-1).
• Characteristics: Under the above described conditions, to avoid precipitation or protein dimerization, the product can be concentrated to a maximum of 0,7mM under Inert atmosphere.
• Storage: -20°C. The protein is stable at 4°C for at least 2 weeks and at 25°C for at least several hours. After initial defrost, aliquot protein into individual tubes and refreeze at –20°C. Avoid repeated freeze/defrost cycles.

Gene Information

• Gene Name: SCO2 SCO cytochrome oxidase deficient homolog 2 (yeast) [ Homo sapiens ]
• Synonyms: SCO2; SCO cytochrome oxidase deficient homolog 2 (yeast); SCO1L; MGC125823; MGC125825; SCO2; SCO (cytochrome oxidase deficient, yeast) homolog 2;Protein SCO2 homolog, mitochondrial
• Gene ID: 9997
• mRNA Refseq: NM_005138
• Protein Refseq: NP_005129
• MIM: 604272
• UniProt ID: O43819
• Chromosome Location: 22q13.33
• Function: copper ion binding;metal ion binding