SCO2
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Official Full Name
SCO cytochrome oxidase deficient homolog 2 -
Overview
Cytochrome c oxidase (COX) catalyzes the transfer of electrons from cytochrome c to molecular oxygen, which helps to maintain the proton gradient across the inner mitochondrial membrane that is necessary for aerobic ATP production. Human COX is a multimeric protein complex that requires several assembly factors; this gene encodes one of the COX asembly factors. The encoded protein is a metallochaperone that is involved in the biogenesis of cytochrome c oxidase subunit II. Mutations in this gene are associated with fatal infantile encephalocardiomyopathy. -
Synonyms
SCO2;SCO cytochrome oxidase deficient homolog 2 (yeast);SCO (cytochrome oxidase deficient, yeast) homolog 2;protein SCO2 homolog, mitochondrial;SCO1L;cytochrome oxidase deficient homolog 2;MGC125823;MGC125825
Recombinant Proteins
- Mouse
- Human
- Zebrafish
- Mammalian Cells
- E.coli
- HEK293
- His
- Non
- His&SUMO
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| SCO2-14770M | Recombinant Mouse SCO2 Protein | Mammalian Cells | Mouse | His |
|
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| Sco2-170H | Recombinant Human SCO2 | E.coli | Human | Non | 100-266 a.a. |
|
| SCO2-3449H | Recombinant Human SCO2 protein, His-tagged | E.coli | Human | His | 42-266 a.a. |
|
| SCO2-4247Z | Recombinant Zebrafish SCO2 | Mammalian Cells | Zebrafish | His |
|
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| SCO2-2025HCL | Recombinant Human SCO2 293 Cell Lysate | HEK293 | Human | Non |
|
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| SCO2-2836H | Recombinant Human SCO2 Protein (Gly42-Ser266), His tagged | E.coli | Human | His | Gly42-Ser266 |
|
| SCO2-3149H | Recombinant Human SCO2 protein, His-tagged | E.coli | Human | His | 1-266 aa |
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| SCO2-3473H | Recombinant Human SCO2 protein, His-SUMO-tagged | E.coli | Human | His&SUMO | 43-266aa |
|
| SCO2-7942M | Recombinant Mouse SCO2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| SCO2-7942M-B | Recombinant Mouse SCO2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
Involved Pathway
SCO2 involved in several pathways and played different roles in them. We selected most pathways SCO2 participated on our site, such as Central carbon metabolism in cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with SCO2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Central carbon metabolism in cancer | PDK1,SIRT6,AKT2,NTRK3,SLC2A2,RAF1,IDH1,MAPK1,FGFR3,KIT |
Protein Function
SCO2 has several biochemical functions, for example, copper ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by SCO2 itself. We selected most functions SCO2 had, and list some proteins which have the same functions with SCO2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| copper ion binding | AOC2,LOXL5A,LOXL3,MT1,PRND,SNCA,F8,MOXD1L,TYRP1B,CP |
| protein binding | MMP2,PPP1R12A,UBASH3B,CTNNB1,SMAD7,POLR1C,LGALS8,TRAPPC10,TTC3,TARBP2 |
Interacting Protein
SCO2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with SCO2 here. Most of them are supplied by our site. Hope this information will be useful for your research of SCO2.
MAP3K3;MYC;1C;PHKG2;MAGEA10;Prkacb;ILK;ARMC6;P
Resources
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References
- Coenen, MJH; van den Heuvel, LP; et al. Cytochrome c oxidase biogenesis in a patient with a mutation in COX10 gene. ANNALS OF NEUROLOGY 56:560-564(2004).
- Takahashi, Y; Kako, K; et al. Mammalian copper chaperone Cox17p has an essential role in activation of cytochrome c oxidase and embryonic development. MOLECULAR AND CELLULAR BIOLOGY 22:7614-7621(2002).
- Jaksch, M; Paret, C; et al. Cytochrome c oxidase deficiency due to mutations in SCO2, encoding a mitochondrial copper-binding protein, is rescued by copper in human myoblasts. HUMAN MOLECULAR GENETICS 10:3025-3035(2001).
