Recombinant Human RIN2 Protein, GST-tagged

• Cat.No.: RIN2-722H
• Product Overview: Recombinant Human RIN2 protein (residues (785-879) ) was expressed in E. coli with GST tag.

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Protein Length: 785-879 a.a.
• Description: RIN2, only expressed in neurons, preferentially interacts with the GTP form of Rab5 rather than the GDP form, although it enhances the guanine exchange reaction on Rab5. Moreover, gel filtration and immunoprecipitation analyses suggest that RIN2 could form a tetramer composed of anti-parallel linkage of two parallel dimers. These results suggest that RIN2 may function as an upstream activator and/or downstream effector for Rab5 in the endocytic pathway. Additionally RIN2 interacts with several Ras proteins, it binds the GTP-loaded forms of H-Ras, TC21 and M-Ras.
• Form: 25 mM HEPES pH 7.5, 50 mM NaCl, 1 mM EDTA and 50% glycerol
• Purity: > 95 % (SDS-PAGE)
• Storage: Store at -20 centigrade, avoid freeze/thaw cycles.

Gene Information

• Gene Name: RIN2 RAB5 interacting protein 2 [ Homo sapiens ]
• Official Symbol: RIN2
• Synonyms: MACS; RASSF4
• Gene ID: 54453
• mRNA Refseq: NM_018993
• Protein Refseq: NP_061866
• MIM: 610222
• UniProt ID: Q8WYP3