Recombinant Human RGS5, His-tagged

• Cat.No.: RGS5-3617H
• Product Overview: Recombinanthuman RGS5 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: RGS5, also known as regulator of G-protein signaling 5, binds directly to activated G alpha subunits and act as GTPase-activating proteins(GAPs) to attenuate and/or modulate hormone and neurotransmitter receptor-initiated signaling by both G alpha-GTP and G beta gamma. Vascular endothelial cells express the RGS protein RGS5, where it correlates with capillary morphogenesis, thus rendering it a candidate gene involved in capillary growth, angiogenesis, and also potentially the pathophysiology of stroke.
• Form: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 20% glycerol, 0.1M NaCl,1mM DTT
• Molecular Weight: 23.5 kDa (205aa), confirmed by MALDI-TOF
• Purity: > 90% by SDS - PAGE
• Concentration: 0.5 mg/ml (determined by Bradford assay)
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MGSHMCKGLA ALPHSCLERA KEIKIKLGIL LQKPDSVGDL VIPYNEKPEK PAKTQKTSLD EALQWRDSLDKLLQNNYGLA SFKSFLKSEF SEENLEFWIA CEDYKKIKSP AKMAEKAKQI YEEFIQTEAP KEVNIDHFTK DITMKNLVEP SLSSFDMAQKRIHALMEKDS LPRFVRSEFY QELIK
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: RGS5 regulator of G-protein signaling 5 [ Homo sapiens ]
• Official Symbol: RGS5
• Synonyms: RGS5; MST092; MST106; MST129; MSTP032; MSTP092; regulator of G-protein signaling 5; OTTHUMP00000032361; OTTHUMP00000232302; MSTP106; MSTP129
• Gene ID: 8490
• mRNA Refseq: NM_001195303
• Protein Refseq: NP_001182232
• MIM: 603276
• UniProt ID: O15539
• Chromosome Location: 1q23.1
• Function: GTPase activator activity; signal transducer activity