RGS5
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Official Full Name
regulator of G-protein signaling 5 -
Overview
This gene encodes a member of the regulators of G protein signaling (RGS) family. The RGS proteins are signal transduction molecules which are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. This gene is a hypoxia-inducible factor-1 dependent, hypoxia-induced gene which is involved in the induction of endothelial apoptosis. This gene is also one of three genes on chromosome 1q contributing to elevated blood pressure. Alternatively spliced transcript variants encoding different isoforms have been identified. -
Synonyms
RGS5;regulator of G-protein signaling 5;regulator of G protein signalling 5;MST092;MST106;MST129;MSTP032;MSTP092;MSTP106;MSTP129;RGS 5;RGS5_HUMAN
Recombinant Proteins
- Mouse
- Human
- Rhesus macaque
- Mammalian Cells
- E.coli
- HEK293
- His
- His&T7
- Non
- GST
- His&Fc&Avi
Involved Pathway
RGS5 involved in several pathways and played different roles in them. We selected most pathways RGS5 participated on our site, such as Calcium Regulation in the Cardiac Cell,Myometrial Relaxation and Contraction Pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with RGS5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Myometrial Relaxation and Contraction Pathways | RAMP1,CORIN,RGS7,GPR182,GABPA,RGS14,RGS11,CNN1,CNN2,CRH |
| Calcium Regulation in the Cardiac Cell | RGS20,CHRM5,KCNJ3,CASQ2,KCNB1,GJB3,PKIG,ANXA6,GJA4,GJA10 |
Protein Function
RGS5 has several biochemical functions, for example, GTPase activator activity. Some of the functions are cooperated with other proteins, some of the functions could acted by RGS5 itself. We selected most functions RGS5 had, and list some proteins which have the same functions with RGS5. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| GTPase activator activity | ARHGAP22,RACGAP1,CHML,TBC1D9,TBC1D19,ADAP1,ERRFI1,USP6NL,SRGAP3,RGS5A |
Interacting Protein
RGS5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RGS5 here. Most of them are supplied by our site. Hope this information will be useful for your research of RGS5.
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