Recombinant Human RARA Protein, N-GST tagged

• Cat.No.: RARA-15H
• Product Overview: Recombinant RAR alpha Ligand Binding Domain was expressed in a bacterial system and purified by an affinity column in combination with FPLC chromatography.
  1 unit equals 1 nanogram (ng)
  0.4 mg/mL in 1 × dilution buffer A
  1 × RAR dilution buffer (A)

Specification

• Species: Human
• Source: E.coli
• Tag: GST
• Description: This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus.
• Molecular Mass: 60.6 kDa
• Purity: The purified recombinant protein is greater than 95% homogeneous and contains no detectable protease, DNase and RNase activity.
• Applications: Research Use Only, not for Drug or Diagnostic purposes. RARα-LBD can be applied in in vitro transcription assays, DNA-protein and protein-protein interaction assays.
• GeneID: 5914
• References: 1. Hart S.M. (2002) Biol. Res. 35, 295-3003
  2. Kastner et al. (1995) Cell, 83, 859-869
  3. Leid et al., (1992) Trends Biochem. Sci. 17, 427-433

Gene Information

• Gene Name: RARA retinoic acid receptor alpha [ Homo sapiens (human) ]
• Official Symbol: RARA
• Synonyms: RARA; retinoic acid receptor alpha; RAR; NR1B1; RARalpha; retinoic acid receptor alpha; PML-DDX5-RARA fusion; PML-DDX5-RARA fusion protein; RAR-alpha; nuclear receptor subfamily 1 group B member 1; nucleophosmin-retinoic acid receptor alpha fusion protein NPM-RAR long form; retinoic acid receptor, alpha polypeptide
• mRNA Refseq: NM_000964
• Protein Refseq: NP_000955
• MIM: 180240
• UniProt ID: P10276