RARA
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Official Full Name
retinoic acid receptor, alpha -
Overview
This gene represents a nuclear retinoic acid receptor. The encoded protein, retinoic acid receptor alpha, regulates transcription in a ligand-dependent manner. This gene has been implicated in regulation of development, differentiation, apoptosis, granulopoeisis, and transcription of clock genes. Translocations between this locus and several other loci have been associated with acute promyelocytic leukemia. Alternatively spliced transcript variants have been found for this locus. -
Synonyms
RARA;retinoic acid receptor, alpha;retinoic acid receptor alpha;NR1B1;RAR;RAR-alpha;retinoic acid receptor, alpha polypeptide;nuclear receptor subfamily 1 group B member 1;retinoic acid nuclear receptor alpha variant 1;retinoic acid nuclear recep
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- E.coli
- Sf9 Insect Cell
- Mammalian Cell
- Insect Cell
- HEK293
- His
- GST
- Non
- His&GST
- His&T7
- His&Fc&Avi
Involved Pathway
RARA involved in several pathways and played different roles in them. We selected most pathways RARA participated on our site, such as Pathways in cancer,Transcriptional misregulation in cancer,Acute myeloid leukemia, which may be useful for your reference. Also, other proteins which involved in the same pathway with RARA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Transcriptional misregulation in cancer | HHEX,SLC45A3,RUNX2,PTCRA,JMJD1C,RUNX1,PRCC,MAF,DOT1L,TP53 |
| Pathways in cancer | BMP2,BRAF,PTCH1,Fasl,MSH2,PGF,FGF9,AGTR1B,RXRA,RUNX1T1 |
| Acute myeloid leukemia | CHUK,RPS6KB2,STAT5A,AKT3,JUP,HRAS,SOS1,MAP2K2,PIK3R5,FLT3 |
Protein Function
RARA has several biochemical functions, for example, RNA polymerase II regulatory region sequence-specific DNA binding,alpha-actinin binding,chromatin DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by RARA itself. We selected most functions RARA had, and list some proteins which have the same functions with RARA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein domain specific binding | HIST2H4A,SNCA,ETV6,CHMP1A,PPP3R1,VRK2,SHROOM2,CTBP1,YWHAQ,RAB27A |
| chromatin DNA binding | EP300,FOXO3,NOTCH1,GRHL2,RUVBL2,XBP1,MYOD1,PER1,MYOG,FOXC2 |
| retinoic acid-responsive element binding | RXRA,ZFP536 |
| transcription factor binding | HDAC4,GTF2B,ZFPM2,ARID5A,IFI16,THRA,PPP1R13BB,NFYC,TCF12,DOT1L |
| enzyme binding | PYCARD,THRB,WWOX,SLC27A2,CYP1A2,TSPAN33,PCBP2,PDE4D,DNMT3L,TRP53 |
| transcription corepressor activity | JUB,HDAC7A,ANKRD1,NANOG,RCOR2,SIRT1,MNT,SKIL,HDAC7,PPP1R13L |
| transcription coactivator activity | MAK,YAP1,ACTL6B,PRMT2,PER2,SOX17,YAF2,ELF3,TADA2B,SRA1 |
| protein binding | ERGIC1,PAK6,MSH2,GEMIN7,IFITM3,MEIS1,SPAG5,ANKHD1,LCE1B,TEX14 |
| receptor binding | PRDX5,TENM2,HAMP,GDNF,PICK1,SCYL2,ANGPT2,TNFSF4,APLN,SERPINE1 |
Interacting Protein
RARA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with RARA here. Most of them are supplied by our site. Hope this information will be useful for your research of RARA.
RXRG;RXRA;MED1
Resources
Research Area
Transcription Regulators in VSMCMultiple Sclerosis and Myelin Related Molecules
Acne vulgaris Therapeutic Targets
Related Services
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References
- Yin, CC; Jain, N; et al. Identification of a Novel Fusion Gene, IRF2BP2-RARA, in Acute Promyelocytic Leukemia. JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK 13:19-22(2015).
- Mueller, GA; Maleki, SJ; et al. Identification of Maillard reaction products on peanut allergens that influence binding to the receptor for advanced glycation end products. ALLERGY 68:1546-1554(2013).
