Recombinant Human RALB, His-tagged

• Cat.No.: RALB-3390H
• Product Overview: Recombinant human RALB protein, fused to His-tag at N-terminus, was expressed inE.coliand purified by using conventional chromatography. MW = 25.6 kDa (227aa).

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 1-203 a.a.
• Description: RALB, also called Ras-related protein Ral-B, belongs to subfamily of Ras-related GTPases. This protein is activated by a unique nucleotide exchange factor, Ral GDS, and deactivated by a distinct GTPase-activating protein. It plays a role in the late stages of cytokinesis and is required for the abscission of the bridge joining the sister cells emerging from mitosis. Also it is required for suppression of apoptosis.
• Form: Liquid. 20mM Tris-HCl buffer (pH8.0) containing 10% glycerol 0.1M NaCl, 1mM DTT.
• Purity: > 90% by SDS - PAGE.
• Concentration: 1.0 mg/ml (determined by Bradford assay).
• Sequences Of Amino Acids: MGSSHHHHHH SSGLVPRGSH MGSHMAANKS KGQSSLALHK VIMVGSGGVG KSALTLQFMY DEFVEDYEPT KADSYRKKVV LDGEEVQIDI LDTAGQEDYA AIRDNYFRSG EGFLLVFSIT EHESFTATAE FREQILRVKA EEDKIPLLVV GNKSDLEERR QVPVEEARSK AEEWGVQYVE TSAKTRANVD KVFFDLMREI RTKKMSENKD KNGKKSSKNK KSFKERC.
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
• Pathways: Pancreatic cancer; Pathways in cancer; Signalling by NGF

Gene Information

• Gene Name: RALB v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein) [ Homo sapiens ]
• Synonyms: v-ral simian leukemia viral oncogene homolog B (ras related; GTP binding protein); RALB;ras-related protein Ral-B; OTTHUMP00000204385; OTTHUMP00000207264; RAS-like protein B; GTP binding protein
• Gene ID: 5899
• mRNA Refseq: NM_002881
• Protein Refseq: NP_002872
• MIM: 179551
• UniProt ID: P11234
• Chromosome Location: 2cen-q13
• Function: GTP binding; GTPase activity; nucleotide binding; protein binding