Recombinant Human PTPRM, GST-tagged
Cat.No. : | PTPRM-382H |
Product Overview : | Recombinant human PTPRM (764-1452) was expressed by baculovirus inSf9 insect cellsusing an N-terminal GST tag. MW = 110 kDa. |
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Species : | Human |
Source : | Sf9 Cells |
Tag : | GST |
Protein Length : | 764-1452 a.a. |
Description : | PTPRM is a member of the protein tyrosine phosphatase family and can participate in a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPRM has been shown to mediate cell-cell aggregation through the interaction with another molecule of PTPRM on an adjacent cell. PTPRM can interact with scaffolding protein RACK1/GNB2L1 and this interaction may be necessary for downstream signaling in response to cell-cell adhesion. PTPRM has been shown to be expressed in human pulmonary vascular endothelia where it directly binds to VE-cadherin and regulates both the tyrosine phosphorylation state of VE-cadherin and barrier integrity. |
Sequence : | 764-1452. |
Applications : | Western Blot. |
Storage And Stability : | Store product at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. |
Gene Name | PTPRM protein tyrosine phosphatase, receptor type, M [ Homo sapiens ] |
Synonyms | PTPRM; protein tyrosine phosphatase, receptor type, M; RPTPM; RPTPU; PTPRL1; hR-PTPu; R-PTP-MU; MGC166994; protein tyrosine phosphatase mu; protein tyrosine phosphatase, receptor type, mu polypeptide; EC 3.1.3.48 |
Gene ID | 5797 |
mRNA Refseq | NM_001105244 |
Protein Refseq | NP_001098714 |
MIM | 176888 |
UniProt ID | P28827 |
Chromosome Location | 18p11.2 |
Pathway | Adherens junction; Cell adhesion molecules (CAMs) |
Function | cadherin binding; hydrolase activity; protein binding; receptor activity; transmembrane receptor protein tyrosine phosphatase activity |
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Not For Human Consumption!
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