Recombinant Human PTPRM, GST-tagged
Cat.No. : | PTPRM-1861H |
Product Overview : | Recombinant humanPTPRM was expressed in anE.coliexpression system using a N-terminal GST tag. MW=56.2kDa. |
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Species : | Human |
Source : | E.coli |
Tag : | GST |
Description : | PTPRM is a member of the protein tyrosine phosphatase family and can participate in a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPRM has been shown to mediate cell-cell aggregation through the interaction with another molecule of PTPRM on an adjacent cell. PTPRM can interact with scaffolding protein RACK1/GNB2L1 and this interaction may be necessary for downstream signaling in response to cell-cell adhesion. PTPRM has been shown to be expressed in human pulmonary vascular endothelia where it directly binds to VE-cadherin and regulates both the tyrosine phosphorylation state of VE-cadherin and barrier integrity. |
Purity : | > 95% by SDS-PAGE. |
Specific Activity : | 680 U/ug. One unit will hydrolyze 1 pmol p-nitrophenyl phosphate per minute at pH 7.4 and 30°C. Assay buffer: 50 mM HEPES, pH 7.4, 2 mM EDTA, 3 mM DTT, 100 mM NaCl, 50 mM pNPP. |
Application : | Useful for the study of enzyme kinetics, regulation, and to dephosphorylate target substrates. |
Formulated In : | 25 mM Tris-HCl, pH 8.0, 75 mM NaCl, 0.05% Tween-20, 50% glycerol, 2 mM EDTA, 1 mM DTT, 10 mM glutathione. |
Stability : | >6 months at –80°C. |
Gene Name | PTPRM protein tyrosine phosphatase, receptor type, M [ Homo sapiens ] |
Synonyms | PTPRM; protein tyrosine phosphatase, receptor type, M; RPTPM; RPTPU; PTPRL1; hR-PTPu; R-PTP-MU; MGC166994; protein tyrosine phosphatase mu; protein tyrosine phosphatase, receptor type, mu polypeptide; EC 3.1.3.48 |
Gene ID | 5797 |
mRNA Refseq | NM_001105244 |
Protein Refseq | NP_001098714 |
MIM | 176888 |
UniProt ID | P28827 |
Chromosome Location | 18p11.2 |
Pathway | Adherens junction; Cell adhesion molecules (CAMs) |
Function | cadherin binding; hydrolase activity; protein binding; receptor activity; transmembrane receptor protein tyrosine phosphatase activity |
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Not For Human Consumption!
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