PTPRM
-
Official Full Name
protein tyrosine phosphatase, receptor type, M -
Overview
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic tra -
Synonyms
PTPRM;protein tyrosine phosphatase, receptor type, M;PTPRL1;receptor-type tyrosine-protein phosphatase mu;hR PTPu;RPTPU;protein tyrosine phosphatase mu;protein-tyrosine phosphatase mu;protein tyrosine phosphatase, receptor type, mu polypeptide;RP
Recombinant Proteins
- Human
- Mouse
- E.coli
- Mammalian Cells
- Sf9 Cells
- HEK293
- Non
- His
- GST
- His&T7
- His&Fc&Avi
Involved Pathway
PTPRM involved in several pathways and played different roles in them. We selected most pathways PTPRM participated on our site, such as Cell adhesion molecules (CAMs),Adherens junction, which may be useful for your reference. Also, other proteins which involved in the same pathway with PTPRM were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cell adhesion molecules (CAMs) | JAM2A,ALCAM,PVRL2,CD226,HLA-DOB,CLDN10A,CLDNE,NCAM1B,VTCN1,CLDNG |
| Adherens junction | PTPRFB,WASF1,PVRL3B,FYN,ACTN3A,MLLT4,TJP1,INSRA,MAPK3,ACTN2B |
Protein Function
PTPRM has several biochemical functions, for example, cadherin binding,identical protein binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PTPRM itself. We selected most functions PTPRM had, and list some proteins which have the same functions with PTPRM. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| cadherin binding | P2RX4,CTNNB1,JUPA,OLFM4,CDK5R1,CD46,PSEN1,NEO1,MMP24,CTNNAL1 |
| identical protein binding | GOT1,DRD4,UGP2,RILPL2,SERPINA1D,SYNE1,CHMP4A,SERPINA1A,DPP4,GLUL |
| protein binding | UPF3A,EVC2,FAM13C,YIPF3,CREB5,AXIN2,BAG6,EDDM3B,Abcb1b,SAV1 |
| protein tyrosine phosphatase activity | DUSP22A,SSH3,TPTE,EYA2,DUSP10,MTMR1,DNAJC6,PTPN13,MTMR14,MTMR1B |
| transmembrane receptor protein tyrosine phosphatase activity | PTPRN2,PTPRR,EVLA,PTPRF,PTPRE,PTPRA,PTPRUB,PTPN6,PTPRD,PTPRC |
Interacting Protein
PTPRM has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PTPRM here. Most of them are supplied by our site. Hope this information will be useful for your research of PTPRM.
LCK;Cdh1;Cdh2;Cdh4;nagA
Resources
Research Area
Phosphatases and RegulatorsAdherens Junction Proteins in Endothelial Cells
Adherens Junction Proteins in VSMC
Related Services
Related Products
References
- Luckerath, K; Kirkin, V; et al. Immune modulation by Fas ligand reverse signaling: lymphocyte proliferation is attenuated by the intracellular Fas ligand domain. BLOOD 117:519-529(2011).
- Charba, DS; Wiggins, RC; et al. Antibodies to protein tyrosine phosphatase receptor type O (PTPro) increase glomerular albumin permeability (P(alb)). AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY 297:F138-F144(2009).
