Recombinant Human PTPRM , GST-tagged

• Cat.No.: PTPRM-7017H
• Product Overview: Recombinant human PTPRM (764-1452) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.

Specification

• Species: Human
• Source: Sf9 Cells
• Tag: GST
• Protein Length: 764-1452 aa
• Description: PTPRM is a member of the protein tyrosine phosphatase family and can participate in a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. PTPRM has been shown to mediate cell-cell aggregation through the interaction with another molecule of PTPRM on an adjacent cell. PTPRM can interact with scaffolding protein RACK1/GNB2L1 and this interaction may be necessary for downstream signaling in response to cell-cell adhesion. PTPRM has been shown to be expressed in human pulmonary vascular endothelia where it directly binds to VE-cadherin and regulates both the tyrosine phosphorylation state of VE-cadherin and barrier integrity.
• Form: Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.
• Molecular Mass: ~110 kDa
• Purity: >90%
• Applications: Western Blot
• Storage: Store at –70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. Avoid freeze/thaw cycles.
• Concentration: 0.2 μg/μl

Gene Information

• Gene Name: PTPRM protein tyrosine phosphatase, receptor type, M [ Homo sapiens ]
• Official Symbol: PTPRM
• Synonyms: PTPRM; protein tyrosine phosphatase, receptor type, M; PTPRL1; receptor-type tyrosine-protein phosphatase mu; hR PTPu; RPTPU; protein tyrosine phosphatase mu; protein-tyrosine phosphatase mu; protein tyrosine phosphatase, receptor type, mu polypeptide; RPTPM; hR-PTPu; R-PTP-MU; MGC166994
• Gene ID: 5797
• mRNA Refseq: NM_001105244
• Protein Refseq: NP_001098714
• MIM: 176888
• UniProt ID: P28827
• Chromosome Location: 18p11.2
• Pathway: Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Cell adhesion molecules (CAMs), organism-specific biosystem; Cell adhesion molecules (CAMs), conserved biosystem; Nectin adhesion pathway, organism-specific biosystem
• Function: cadherin binding; hydrolase activity; protein binding; protein tyrosine phosphatase activity; receptor activity; transmembrane receptor protein tyrosine phosphatase activity