Recombinant Human PTGES2, His-tagged

• Cat.No.: PTGES2-30326TH
• Product Overview: Recombinant full length Human PTGES2 with an N terminal His tag; 206 amino acids with the tag; predicted mwt: 23.5 kDa.

Specification

• Description: The protein encoded by this gene is a membrane-associated prostaglandin E synthase, which catalyzes the conversion of prostaglandin H2 to prostaglandin E2. This protein also has been shown to activate the transcription regulated by a gamma-interferon-activated transcription element (GATE). Multiple transcript variants have been found for this gene.
• Protein length: 206 amino acids
• Conjugation: HIS
• Molecular Weight: 23.500kDa inclusive of tags
• Source: E. coli
• Tissue specificity: Widely expressed. Expressed in the heart, including apex, inter-ventricular septum, both atria and ventricles, but not in the aorta. Also expressed in fetal heart. Detected in various regions of the brain: cerebellum; occipital, frontal and parietal lobes
• Form: Liquid
• Purity: >95% by SDS-PAGE
• Storage buffer: Preservative: NoneConstituents: 20% Glycerol, 0.2M Sodium chloride, 20mM Tris HCl, 2mM DTT, pH 8.0
• Storage: Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Sequences of amino acids: MGSSHHHHHHSSGLVPRGSHMKAVNEQGKEVTEFGNKYWLMLNEKEAQQVYGGKEARTEEMKWRQWADDWLVHLISPNVYRTPTEALASFDYIVREGKFGAVEGAVAKYMGAAAMYLISKRLKSRHRLQDNVREDLYEAADKWVAAVGKDRPFMGGQKPNLADLAVYGVLRVMEGLDAFDDLMQHTHIQPWYLRVERAITEASPAH
• Sequence Similarities: Belongs to the GST superfamily.Contains 1 glutaredoxin domain.Contains 1 GST C-terminal domain.

Gene Information

• Gene Name: PTGES2 prostaglandin E synthase 2 [ Homo sapiens ]
• Official Symbol: PTGES2
• Synonyms: PTGES2; prostaglandin E synthase 2; C9orf15, chromosome 9 open reading frame 15; FLJ14038
• Gene ID: 80142
• mRNA Refseq: NM_025072
• Protein Refseq: NP_079348
• MIM: 608152
• Uniprot ID: Q9H7Z7
• Chromosome Location: 9q34.12
• Pathway: Arachidonic acid metabolism, organism-specific biosystem; Arachidonic acid metabolism, conserved biosystem; Eicosanoid Synthesis, organism-specific biosystem; IFN-gamma pathway, organism-specific biosystem; Metabolic pathways, organism-specific biosystem
• Function: DNA binding; electron carrier activity; isomerase activity; prostaglandin-E synthase activity; protein disulfide oxidoreductase activity