Recombinant Human PR domain containing 1, with ZNF domain Protein, His&Flag&StrepII tagged

• Cat.No.: PRDM1-123H
• Product Overview: Recombinant human PRDM1 protein (O75626) (Lys 38-Gln 223) with a Twin strep tag at the N-terminus and both His, Flag tag at the C-terminus was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: Flag&His&Twin Strep
• Protein Length: 38-223aa
• Description: Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene.
• Tag: N-Twin strep and C-His&Flag
• Molecular Mass: 28.4 kDa
• Endotoxin: Less than 1.0 EU/μg by the LAL method.
• Purity: >95% as determined by SDS-PAGE.
• Storage: Please avoid repeated freeze-thaw cycles. Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade. It is recommended that aliquot the reconstituted solution to minimize freeze-thaw cycles.
• Storage Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4, 5% Trehalose, 5% mannitol.
• Reconstitution: Reconstitute at 250 μg/mL in sterile water.

Gene Information

• Gene Name: PRDM1 PR domain containing 1, with ZNF domain [ Homo sapiens (human) ]
• Official Symbol: PRDM1
• Synonyms: PRDM1; PR domain containing 1, with ZNF domain; BLIMP1; PR domain zinc finger protein 1; PRDI BF1; BLIMP-1; PRDI-binding factor-1; B-lymphocyte-induced maturation protein 1; beta-interferon gene positive-regulatory domain I binding factor; PRDI-BF1; MGC118922; MGC118923; MGC118924; MGC118925
• Gene ID: 639
• mRNA Refseq: NM_001198
• Protein Refseq: NP_001189
• MIM: 603423
• UniProt ID: O75626