PRDM1
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Official Full Name
PR domain containing 1, with ZNF domain -
Overview
This gene encodes a protein that acts as a repressor of beta-interferon gene expression. The protein binds specifically;to the PRDI (positive regulatory domain I element) of the beta-IFN gene promoter. Transcription of this gene increases;upon virus induction. Two alternatively spliced transcript variants that encode different isoforms have been reported. -
Synonyms
PRDM1;PR domain containing 1, with ZNF domain;PR domain zinc finger protein 1;PR domain-containing protein 1;B lymphocyte induced maturation protein;B lymphocyte-induced maturation protein 1;beta-interferon gene positive regulatory domain I-binding factor;Blimp1;Blimp-1;PRDI-BF1;ZNFPR1A1
Recombinant Proteins
- Mouse
- Human
- Rat
- Mammalian Cells
- HEK293
- E.coli
- His
- Non
- Flag
- Flag&His&Twin Strep
- His&T7
- Avi&Fc&His
Involved Pathway
PRDM1 involved in several pathways and played different roles in them. We selected most pathways PRDM1 participated on our site, such as Direct p53 effectors,NOD pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PRDM1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Direct p53 effectors | TRIAP1,GDF15,PPM1J,ARID3A,GADD45A,FOXA1,NDRG1,SMARCA4,S100A2,CD82 |
| NOD pathway | NLRP12,COPS6,AAMP,SUGT1,NLRP7,NLRP10,NLRP3,NLRP4,NLRP2 |
Protein Function
PRDM1 has several biochemical functions, for example, RNA polymerase II core promoter proximal region sequence-specific DNA binding,histone deacetylase binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PRDM1 itself. We selected most functions PRDM1 had, and list some proteins which have the same functions with PRDM1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | EDDM3B,UBE3A,TBL3,TNPO3,NCKAP1L,MRAS,CDK17,RPRD1B,SCRN1,DMKN |
| methyltransferase activity | SMYD4,GART,RG9MTD1,NSUN4,DNMT3,METTL25,NDUFAF5,SMYD2B,WBP7,PCMTL |
| transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding | RCOR1,PROX1A,CC2D1A,MXD1,E2F8,ZKSCAN3,GFI1,REST,ASCL2,TFAP2C |
| metal ion binding | ZNF878,GALNT5,CSGALNACT1,BCL6AB,OBSCN,TROVE2,ZRANB3,ITPK1A,SP7,POLM |
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | POU4F3,RUNX2,MAFA,TFE3,SIX2,SRF,EBF1,FLI1,ELK1,TCF3A |
| histone deacetylase binding | CCND1,HDAC3,HDAC1,CBX5,TFAP4,BRMS1LA,SKOR2,SP1,YY1,FOXP3 |
| transcription factor activity, sequence-specific DNA binding | ZNF75D,MLXIPL,ZNF584,MESPBA,ZNF394,FOXA1,SALL1A,POU1F1,ALX3,EGR1 |
Interacting Protein
PRDM1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PRDM1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PRDM1.
PIAS1;HSP90AB1;SUMO1;CDC37;ATXN1;clpB;ifnl1_human_gene
Resources
Research Area
Germ Cell MarkersCancer Stem Cell Transcription Factors
B Cell Transcription Factors
T Follicular Helper (Tfh) Cells
Related Services
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References
- Kitabatake, M; Soma, M; et al. JNK Regulatory Molecule G5PR Induces IgG Autoantibody-Producing Plasmablasts from Peritoneal B1a Cells. JOURNAL OF IMMUNOLOGY 194:1480-1488(2015).
- White, CA; Pone, EJ; et al. Histone Deacetylase Inhibitors Upregulate B Cell microRNAs That Silence AID and Blimp-1 Expression for Epigenetic Modulation of Antibody and Autoantibody Responses. JOURNAL OF IMMUNOLOGY 193:5933-5950(2014).
