Recombinant Human PPP2R4

• Cat.No.: PPP2R4-589H
• Product Overview: Recombinant Human PPP2R4 is expressed inE. coli. The molecular weight of the recombinant Human PPP2R4 is 65 kDa.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Description: Protein phosphatase 2A is one of the four major Ser/Thr phosphatases and is implicated in the negative control of cell growth and division. PPP2R4 serves as a scaffolding molecule to coordinate the assembly of the catalytic (PP2AC, GLO132-001) and variable B subunits, generating functionally diverse heterotrimers of the phosphatase. The A subunit contains 15 tandemly-repeated HEAT sequences which may participate in its function as a scaffolding molecule. The A subunit also serves to regulate the substrate selectivity and allosterically modulates the enzymatic properties of PP2Ac, namely via its polycation response.
• Purity: >90% by SDS-PAGE apparent Mr ~ 65-kDa.
• Supplied: 1 mg in 50 ml 50 mM Tris-HCl pH 7.0 buffer containing 14 mM b-mercaptoethanol, 1 mM benzamidine, 0.1 mM phenylmethanesulfonyl fluoride, 1 mM EDTA and 50% glycerol.
• Storage: Maintain preparations in aliquots at -70℃. Avoid repeated thawing.

Gene Information

• Gene Name: PPP2R4 protein phosphatase 2A activator, regulatory subunit 4 [ Homo sapiens ]
• Synonyms: protein phosphatase 2A activator, regulatory subunit 4; PPP2R4; PP2A; PR53; PTPA; MGC2184; PPP2R4; serine/threonine-protein phosphatase 2A regulatory subunit B"; PP2A, subunit B"; PP2A phosphatase activator; phosphotyrosyl phosphatase activator;protein phosphatase 2A, regulatory subunit B" (PR 53); PP2A subunit B" isoform PR53
• Gene ID: 5524
• mRNA Refseq: NM_021131
• Protein Refseq: NP_066954
• MIM: 600756
• UniProt ID: Q15257
• Chromosome Location: 9q34
• Function: ATP binding; ATPase activity; protein heterodimerization activity;protein homodimerization activity;protein phosphatase 2A binding IDA; protein phosphatase type 2A regulator activity; protein phosphatase type 2A regulator activity; receptor binding; protein tyrosine phosphatase activator activity