PPP2R4

  • Official Full Name

    PPP2R4 protein phosphatase 2A activator, regulatory subunit 4

  • Overview

    Type 2 protein serine/threonine phosphatase (PP2A) is a trimer composed of a catalytic C subunit and two regulatory (A and B) subunits; many isoforms for the A and B subunits have been found. PP2A has a high specific activity against the alpha subunit of phosphorylase kinase and is insensitive to Inhibitor-2. PP2A is distinguishable from PP2B/Calcineurin and PP2C by its partial activity in the absence of divalent cations, and by its high sensitivity to inhibition by okadaic acid. It is also thought to be the principal downmodulator of serine/threonine kinase cascades. PP2B requires Ca2+/calmodulin for activity, and is an activator of NFAT transcription factors. PP2C requires Mg2+, but is insensitive to okadaic acid, microcystin LR, or the calmodulin inhibitor trifluoperazine.

  • Synonyms

    PPP2R4;protein phosphatase 2A activator, regulatory subunit 4;protein phosphatase 2A, regulatory subunit B (PR 53);serine/threonine-protein phosphatase 2A activator;phosphotyrosyl phosphatase activator;PP2A phosphatase activator;PR53;PTPA;PP2A subunit B isoform PR53;serine/threonine-protein phosphatase 2A regulatory subunit B;PP2A;MGC2184

Recombinant Proteins

  • Mouse
  • Human
  • Chicken
  • Zebrafish
  • Mammalian Cells
  • E.coli
  • HEK293
  • His
  • Non
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
PPP2R4-13260M Recombinant Mouse PPP2R4 Protein Mammalian Cells Mouse His
PPP2R4-27572TH Recombinant Human PPP2R4, His-tagged E.coli Human His 104-323 a.a.
PPP2R4-3022C Recombinant Chicken PPP2R4 Mammalian Cells Chicken His
PPP2R4-589H Recombinant Human PPP2R4 E.coli Human Non
PPP2R4-878Z Recombinant Zebrafish PPP2R4 Mammalian Cells Zebrafish His
PPP2R4-2919HCL Recombinant Human PPP2R4 293 Cell Lysate HEK293 Human Non
PPP2R4-7037M Recombinant Mouse PPP2R4 Protein, His (Fc)-Avi-tagged HEK293 Mouse His&Fc&Avi
PPP2R4-7037M-B Recombinant Mouse PPP2R4 Protein Pre-coupled Magnetic Beads HEK293 Mouse

    Involved Pathway

    PPP2R4 involved in several pathways and played different roles in them. We selected most pathways PPP2R4 participated on our site, such as Insulin resistance, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP2R4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Insulin resistance STAT3,PPARA,PTENB,PIK3CG,MAPK8,RELA,PPP1R3DA,GSK3B,PPP1R3C,PPP1CBL

    Protein Function

    PPP2R4 has several biochemical functions, for example, ATP binding,contributes_to ATPase activity,peptidyl-prolyl cis-trans isomerase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP2R4 itself. We selected most functions PPP2R4 had, and list some proteins which have the same functions with PPP2R4. You can find most of the proteins on our site.

    Function Related Protein
    protein tyrosine phosphatase activator activity IGFBP3
    peptidyl-prolyl cis-trans isomerase activity FKBP10,FKBPL,PPIB,PPIF,FKBP2,FKBP5,FKBP11,PPIE,PPIL6,PPIAB
    protein phosphatase 2A binding RPS6KB1,STRN4,PPP2R2A,CTTNBP2NL,HMGCR,SMG7,PTPN1,PPME1,EIF4EBP1,TP53
    protein heterodimerization activity PDSS2,CUL5,HIST1H2AA,LIMK2,IRAK2,ANO2,ADORA2A,SPTA1,PPP3CB,HIST1H4B
    protein homodimerization activity MAOB,VPS4B,TPD52L2,S100A16,MAP3K12,AOC3,S100B,SYT16,GOLGA5,ZHX3
    protein phosphatase type 2A regulator activity PPP2R5CB,ENSA,PPME1,EIF2AK2,PPP2R5A,PPP2R2BB,ENSAA,PPP2R1B,IGBP1,PPP2R2C
    contributes_to ATPase activity ATP5I,RUVBL2,ATP5J,ABCA7,ATP5D,ATP5O,ATP5C1,ATP1B1,MSH2,ATP5J2
    receptor binding PVRL1,ENSA,CNPY3,STOML2,TNFSF13B,JAK2,FGF1A,HLA-G,CTNND1,SCYL2
    protein binding PDGFRB,S100A16,POLR3F,EIF1AD,ST13,SELE,MUC7,EFHC1,LSM11,DCP2

    Interacting Protein

    PPP2R4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP2R4 here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP2R4.

    AMOT;BRINP1;Kiaa1109;TCP1;CCT6A;CCT5;CCT3;CCT8;CCT4;PPP2CA;CCT2;CCT7;AKT1

    Resources

    Research Area

    Phosphatases and Regulators
    Alzheimer's Disease
    Adherens Junction Proteins in Endothelial Cells
    Adherens Junction Proteins in VSMC
    Phosphatases Localized to Focal Adhesions

    References

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