Recombinant Human POLH Protein, MYC/DDK-tagged

• Cat.No.: POLH-2456H
• Product Overview: Recombinant Human POLH protein, fused to MYC/DDK-tagged at C-terminus, was expressed in HEK293.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum. Several transcript variants encoding different isoforms have been found for this gene.
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 78.2 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: POLH polymerase (DNA directed), eta [ Homo sapiens ]
• Official Symbol: POLH
• Synonyms: RAD30; RAD30A; XP-V; XPV
• Gene ID: 5429
• mRNA Refseq: NM_006502
• Protein Refseq: NP_006493
• MIM: 603968
• UniProt ID: Q9Y253