Recombinant Human PISD protein, His-tagged

• Cat.No.: PISD-17H
• Product Overview: Recombinant Human PISD(1-375 aa) fused with His tag was expressed in Insect cells.

Specification

• Species: Human
• Source: Insect Cells
• Tag: His
• Protein Length: 1-375 a.a.
• Description: Phosphatidylserine decarboxylases (PSDs; EC 4.1.1.65) catalyze the formation of phosphatidylethanolamine (PE) by decarboxylation of phosphatidylserine (PS). Type I PSDs, such as PISD, are targeted to the inner mitochondrial membrane by an N-terminal targeting sequence. PISD also contains a conserved LGST motif that functions as an autocatalytic cleavage site where the proenzyme is split into mature alpha and beta subunits (Schuiki and Daum, 2009 [PubMed 19165886]).
• Form: Tris-based buffer,50% glycerol
• AA Sequence: MMCQSEARQGPELRAAKWLHFPQLALRRRLGQLSCMSRPALKLRSWPLTVLYYLLPFGAL RPLSRVGWRPVSRVALYKSVPTRLLSRAWGRLNQVELPHWLRRPVYSLYIWTFGVNMKEA AVEDLHHYRNLSEFFRRKLKPQARPVCGLHSVISPSDGRILNFGQVKNCEVEQVKGVTYS LESFLGPRMCTEDLPFPPAASCDSFKNQLVTREGNELYHCVIYLAPGDYHCFHSPTDWTV SHRRHFPGSLMSVNPGMARWIKELFCHNERVVLTGDWKHGFFSLTAVGATNVGSIRIYFD RDLHTNSPRHSKGSYNDFSFVTHTNREGVPMRKGEHLGEFNLGSTIVLIFEAPKDFNFQL KTGQKIRFGEALGSL
• Purity: >90% (SDS-PAGE)
• Storage: Store at -20 centigrade, for extended storage, conserve at -20 centigrade or -80 centigrade. Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.

Gene Information

• Gene Name: PISD phosphatidylserine decarboxylase [ Homo sapiens ]
• Official Symbol: PISD
• Synonyms: PISD; phosphatidylserine decarboxylase; phosphatidylserine decarboxylase proenzyme; dJ858B16.2; PSDC; PSD; PSSC; DJ858B16; DKFZp566G2246
• Gene ID: 23761
• mRNA Refseq: NM_014338
• Protein Refseq: NP_055153
• MIM: 612770
• UniProt ID: Q9UG56
• Chromosome Location: 22q12.2
• Pathway: FOXA1 transcription factor network, organism-specific biosystem; Glycerophospholipid metabolism, organism-specific biosystem; Glycerophospholipid metabolism, conserved biosystem; Metabolic pathways, organism-specific biosystem
• Function: lyase activity; phosphatidylserine decarboxylase activity