Recombinant Human PGC Protein, His-tagged

Description :	This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1.
Source :	E. coli
Species :	Human
Tag :	His
Form :	20mM Tris, 150mM NaCl,pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
Molecular Mass :	36.9kDa
Identity :	Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.
Protein length :	Val61~Ala388
Endotoxin :	<1.0EU per 1µg (determined by the LAL method)
Purity :	> 95%
Applications :	Positive Control; Immunogen; SDS-PAGE; WB. If bio-activity of the protein is needed, please check active protein
Stability :	The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
Storage :	Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
Reconstitution :	Reconstitute in PBS or others

Gene Name	PGC progastricsin (pepsinogen C) [ Homo sapiens ]
Official Symbol	PGC
Synonyms	PGC; progastricsin (pepsinogen C); gastricsin; pepsin C; pepsinogen C; preprogastricsin; pepsinogen group II; PEPC; PGII; FLJ99563;
Gene ID	5225
mRNA Refseq	NM_001166424
Protein Refseq	NP_001159896
MIM	169740
UniProt ID	P20142