PGC
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Official Full Name
progastricsin (pepsinogen C) -
Overview
This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. -
Synonyms
progastricsin (pepsinogen C);PEPC;PGII;FLJ99563;Gastricsin;PEPC_HUMAN;Pepsinogen C;PGC;Progastricsin;Pepsinogen II
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- E.coli
- HEK293
- Mammalian Cell
- Human Cell
- HEK293 cells
- Human Gastric Mucosa
- HEK293T
- Mammalian cells
- Human
- His
- Non
- His&GST
- Myc&DDK
- His&Fc&Avi
Involved Pathway
PGC involved in several pathways and played different roles in them. We selected most pathways PGC participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with PGC were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
PGC has several biochemical functions, for example, aspartic-type endopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PGC itself. We selected most functions PGC had, and list some proteins which have the same functions with PGC. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| aspartic-type endopeptidase activity | NRIP2,PGA5,PGA4,NRIP3,ASPRV1,Casp3,BACE2,CTSE,PIP,CTSD |
Interacting Protein
PGC has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PGC here. Most of them are supplied by our site. Hope this information will be useful for your research of PGC.
Resources
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References
- Anugraham, M; Everest-Dass, AV; et al. A platform for the structural characterization of glycans enzymatically released from glycosphingolipids extracted from tissue and cells. RAPID COMMUNICATIONS IN MASS SPECTROMETRY 29:545-561(2015).
- Michael, C; Rizzi, AM; et al. Quantitative isomer-specific N-glycan fingerprinting using isotope coded labeling and high performance liquid chromatography-electrospray ionization-mass spectrometry with graphitic carbon stationary phase. JOURNAL OF CHROMATOGRAPHY A 1383:88-95(2015).
