Recombinant Human PER1 protein, His & T7-tagged

• Cat.No.: PER1-1923H
• Product Overview: Recombinant Human PER1 aa. (Ile208~Gln414 (Accession # O15534)) fused with N-terminal His & T7 tag was produced in E. coli cells.

Specification

• Species: Human
• Source: E.coli
• Tag: His&T7
• Protein Length: Ile208~Gln414
• Description: This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers. Alternative splicing has been observed in this gene; however, these variants have not been fully described.
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 26.8kDa
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: >95%
• Applications: SDS-PAGE; WB; ELISA; IP.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage buffer: Supplied as lyophilized form in PBS, pH7.4, containing 5% trehalose, 0.01% sarcosyl.
• Reconstitution: Reconstitute in sterile PBS, pH7.2-pH7.4.
• Isoelectric Point: 9.1

Gene Information

• Gene Name: PER1 period circadian regulator 1 [ Homo sapiens (human) ]
• Official Symbol: PER1
• Synonyms: PER1; period circadian regulator 1; PER; hPER; RIGUI; period circadian protein homolog 1; Period, drosophila, homolog of; circadian clock protein PERIOD 1; circadian pacemaker protein RIGUI; hPER1; period circadian clock 1; period homolog 1
• Gene ID: 5187
• mRNA Refseq: NM_002616.2
• Protein Refseq: NP_002607.2
• UniProt ID: O15534