PER1
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Official Full Name
period homolog 1 (Drosophila) -
Overview
This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. Circadian expression in the suprachiasmatic nucleus continues in constant darkness, and a shift in the light/dark cycle evokes a proportional shift of gene expression in the suprachiasmatic nucleus. The specific function of this gene is not yet known. Alternative splicing has been observed in this gene; however, these variants have not been fully described. -
Synonyms
PER1;period homolog 1 (Drosophila);PER, period (Drosophila) homolog 1;period circadian protein homolog 1;RIGUI;Circadian clock protein PERIOD 1;Circadian clock protein PERIOD1;Circadian pacemaker protein RIGUI;hPER 1;hPER;hPER1;KIAA0482;MGC88021;PER 1;PER;PER1 protein;Period 1;Period drosophila homolog of;Period homolog 1;Period1;Period, drosophila, homolog of
Recombinant Proteins
- Human
- Mouse
- Rat
- S.cerevisiae
- E.coli
- E. coli
- Mammalian Cells
- HEK293
- GST
- His
- Non
- T7
- Avi
- Fc
Involved Pathway
PER1 involved in several pathways and played different roles in them. We selected most pathways PER1 participated on our site, such as Circadian rhythm,Circadian entrainment,Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with PER1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Herpes simplex infection | OAS2,MCRS1,SRSF1A,TRAF6,CASP3B,SRSF4,IFNG,HLA-DOA,HLA-B,IRF3 |
| Circadian rhythm | CRY2,RORA,CLOCK,CSNK1E,PRKAG3,NR1D1,PER3,BHLHE40,RORB,PRKAA2 |
| Circadian entrainment | CALM1,GNG5,PLCB4,GRIN2A,GNGT1,GNG13,NOS1,PLCB3,GRIA3,GNGT2 |
Protein Function
PER1 has several biochemical functions, for example, E-box binding,RNA polymerase II core promoter proximal region sequence-specific DNA binding,chromatin DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PER1 itself. We selected most functions PER1 had, and list some proteins which have the same functions with PER1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| RNA polymerase II core promoter proximal region sequence-specific DNA binding | SMAD1,NFE2L3,RBPJ,ETV2,BATF,ESRRA,MED1,TFE3A,BATF2,CC2D1A |
| E-box binding | CLOCK,TCF4,ATOH8,TAL1,TFAP4,LMO2,NEUROG2,MYC,ASCL2,ASCL1 |
| transcription factor binding | TCF12,HDAC9,GATA3,GTF2F1,ENPP2,HES1,GPX3,POU1F1,HES6,WWP2 |
| transcription factor activity, transcription factor binding | ASCL1B,CRY2,LDB1A,ASCL1,LDB2B,PER2,NEUROG1,LDB1B,MTA2,TRP63 |
| ubiquitin protein ligase binding | IKBKE,AMBRA1,BAG6,POU5F1,VCL,AXIN1,PRKACB,MAGEC2,CDC34B,RB1 |
| kinase binding | DUSP12,BARD1,MIDN,PPP2R5A,TAX1BP1,HSP90AB1,PRDX3,LDHB,ATF5,FAS |
| chromatin DNA binding | SLAMF7,HIST1H1C,NOTCH1,EP300,ATOH1,AASS,H2AFY,MYOD1,XBP1,RXRA |
Interacting Protein
PER1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PER1 here. Most of them are supplied by our site. Hope this information will be useful for your research of PER1.
Cry1;CSNK1E;Csnk1e;TNS2;FAM65B;Csnk1d;GTSE1
Resources
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References
- Ait-Hmyed, O; Felder-Schmittbuhl, MP; et al. Mice lacking Period 1 and Period 2 circadian clock genes exhibit blue cone photoreceptor defects. EUROPEAN JOURNAL OF NEUROSCIENCE 37:1048-1060(2013).
- LeSauter, J; Lambert, CM; et al. Antibodies for Assessing Circadian Clock Proteins in the Rodent Suprachiasmatic Nucleus. PLOS ONE 7:-(2012).
