Recombinant Human PER1 Protein, His-tagged

• Cat.No.: PER1-2576H
• Product Overview: Recombinant Human PER1 Protein (Ile208-Gln414) with a N-His tag was expressed in E. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: Ile208-Gln414
• Description: This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by CLOCK/ARNTL heterodimers but then represses this upregulation in a feedback loop using PER/CRY heterodimers to interact with CLOCK/ARNTL. Polymorphisms in this gene may increase the risk of getting certain cancers. Alternative splicing has been observed in this gene; however, these variants have not been fully described.
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 26.8 kDa
  Accurate Molecular Mass: 27 kDa
• Endotoxin: <1.0 EU per 1µg (determined by the LAL method).
• Purity: > 90%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Gene Information

• Gene Name: PER1 period homolog 1 (Drosophila) [ Homo sapiens (human) ]
• Official Symbol: PER1
• Synonyms: PER1; period homolog 1 (Drosophila); PER, period (Drosophila) homolog 1; period circadian protein homolog 1; RIGUI; hPER1; Period, drosophila, homolog of; circadian clock protein PERIOD 1; circadian pacemaker protein RIGUI; PER; hPER; MGC88021
• Gene ID: 5187
• mRNA Refseq: NM_002616
• Protein Refseq: NP_002607
• MIM: 602260
• UniProt ID: O15534