Recombinant Human NUDT21, His-tagged

Cat. No. :	NUDT21-960H
Description :	TXNL1, also known as TRP32, TXL or TXL-1, is a cytoplasmic protein that participates in endocytotic signaling pathways and acts as a redox sensor. Expressed throughout the body, TXNL1 functions to couple oxidative stress to endocytosis, thereby regulating the GDI. Additionally, overexpression of TXNL1 inhibits cell proliferation by predisposing the cell to G0/G1 arrest, suggesting that TXNL1 also functions as a transcriptional repressor.
Source :	E.coli.
Form :	Liquid. In 20 mM Tris-HCl buffer (pH8.0) containing 0.2M NaCl, 2mM DTT, 20% glycerol.
Molecular Weight :	28.3 kDa (247aa) confirmed by MALDI-TOF.
Purity :	> 90% by SDS - PAGE.
Concentration :	1 mg/ml (determined by Bradford assay).
Sequences Of Amino Acids :	MGSSHHHHHH SSGLVPRGSH MSVVPPNRSQ TGWPRGVTQF GNKYIQQTKP LTLE RTINLY PLTNYTFGTK EPLYEKDSSV AARFQRMREE FDKIGMRRTV EGVL IVHEHR LPHVLLLQLG TTFFKLPGGE LNPGEDEVEG LKRLMTEILG RQDG VLQDWV IDDCIGNWWR PNFEPPQYPY IPAHITKPKE HKKLFLVQLQ EKALF AVPKN YKLVAAPLFE LYDNAPGYGP IISSLPQLLS RFNFIYN.
Storage :	Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.
Pathways :	Transcription; Gene Expression; mRNA Processing

Gene Name	NUDT21 nudix (nucleoside diphosphate linked moiety X)-type motif 21 [ Homo sapiens ]
Synonyms	nudix (nucleoside diphosphate linked moiety X)-type motif 21; CPSF5; CFIM25; DKFZp686H1588; NUDT21; cleavage and polyadenylation specificity factor subunit 5; nudix motif 21; CPSF 25 kDa subunit; pre-mRNA cleavage factor Im (25kD); pre-mRNA cleavage factor Im, 25kD subunit; pre-mRNA cleavage factor Im 25 kDa subunit; nucleoside diphosphate-linked moiety X motif 21; cleavage and polyadenylation specific factor 5, 25 kDa; cleavage and polyadenylation specific factor 5, 25 kD subunit; cleavage and polyadenylation specificity factor 25 kDa subunit; Nudix motif 21; Nucleoside diphosphate-linked moiety X motif 21; Pre-mRNA cleavage factor Im 25 kDa subunit; Cleavage and polyadenylation specificity factor 25 kDa subunit; CPSF25
Gene ID	11051
mRNA Refseq	NM_007006
Protein Refseq	NP_008937
MIM	604978
UniProt ID	O43809
Chromosome Location	16q12.2
Function	AU-rich element binding; contributes_to RNA binding; histone deacetylase binding; hydrolase activity; protein binding; protein homodimerization activity

COA

Cat.No. :	NUDT21-960H
Product Overview :	Recombinant human NUDT21 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.