Recombinant Human NSMAF protein, MYC/DDK-tagged

• Cat.No.: NSMAF-524H
• Product Overview: Recombinant Human NSMAF, transcript variant 1, fused with MYC/DDK tag at C-terminal was expressed in HEK293.

Specification

• Species: Human
• Source: HEK293
• Tag: DDK&Myc
• Description: This gene encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. This protein is required for TNF-mediated activation of neutral sphingomyelinase and may play a role in regulating TNF-induced cellular responses such as inflammation. Alternative splicing results in multiple transcript variants.
• Form: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
• Molecular Mass: 104.2 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Concentration: >50 ug/mL as determined by microplate BCA method

Gene Information

• Gene Name: NSMAF neutral sphingomyelinase (N-SMase) activation associated factor [ Homo sapiens ]
• Official Symbol: NSMAF
• Synonyms: NSMAF; neutral sphingomyelinase (N-SMase) activation associated factor; protein FAN; FAN; factor associated with N-SMase activation; factor associated with neutral sphingomyelinase activation
• Gene ID: 8439
• mRNA Refseq: NM_003580
• Protein Refseq: NP_003571
• MIM: 603043
• UniProt ID: Q92636
• Chromosome Location: 8q12-q13
• Pathway: TNF receptor signaling pathway, organism-specific biosystem; TNF-alpha/NF-kB Signaling Pathway, organism-specific biosystem
• Function: protein binding; receptor signaling protein activity