NSMAF
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Official Full Name
neutral sphingomyelinase (N-SMase) activation associated factor -
Overview
This gene encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. This protein is required for TNF-mediated activation of neutral sphingomyelinase and may play a role in regulating TNF-induced cellular responses such as inflammation. Alternative splicing results in multiple transcript variants. -
Synonyms
NSMAF;neutral sphingomyelinase (N-SMase) activation associated factor;protein FAN;FAN;Factor associated with N SMase activation;Factor associated with neutral sphingomyelinase;Factor associated with neutral sphingomyelinase activation;Neutral sphingomyelinase (N SMase) activation associated factor;OTTHUMP00000226511;OTTHUMP00000226512;factor associated with N-SMase activation
Recombinant Proteins
- Human
- Mouse
- E.coli
- Mammalian Cells
- HEK293
- GST
- His
- His&GST
- Myc&DDK
- Non
- Flag
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NSMAF-1374H | Recombinant Human NSMAF, GST-tagged | E.coli | Human | GST | 568-917aa | |
| NSMAF-10914M | Recombinant Mouse NSMAF Protein | Mammalian Cells | Mouse | His |
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| NSMAF-1124H | Recombinant Human NSMAF protein, His & GST-tagged | E.coli | Human | His&GST | Arg176~Arg575 |
|
| NSMAF-524H | Recombinant Human NSMAF protein, MYC/DDK-tagged | HEK293 | Human | Myc&DDK |
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| NSMAF-3686HCL | Recombinant Human NSMAF 293 Cell Lysate | HEK293 | Human | Non |
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| NSMAF-1844HFL | Recombinant Full Length Human NSMAF protein, Flag-tagged | Mammalian Cells | Human | Flag | Full L. |
|
| NSMAF-3800H | Recombinant Human NSMAF Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| Nsmaf-4510M | Recombinant Mouse Nsmaf Protein, Myc/DDK-tagged | HEK293 | Mouse | Myc&DDK |
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| NSMAF-6221M | Recombinant Mouse NSMAF Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| NSMAF-6221M-B | Recombinant Mouse NSMAF Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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Involved Pathway
NSMAF involved in several pathways and played different roles in them. We selected most pathways NSMAF participated on our site, such as Sphingolipid signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NSMAF were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Sphingolipid signaling pathway | MAP2K2,PIK3CD,PPP2R2C,MAPK3,PDPK1,PLCB1,TRADD,OPRD1,PIK3R1,PLCB2 |
Protein Function
NSMAF has several biochemical functions, for example, phospholipid binding,protein binding,receptor signaling protein activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NSMAF itself. We selected most functions NSMAF had, and list some proteins which have the same functions with NSMAF. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor signaling protein activity | RGS14,FCAR,DCLK1,TYROBP,BAG1,FCGR1A,SMAD1,TIAM2,cgr2b,NCR1 |
| protein binding | AP1G2,KLF10,CHRM3,CASP9,TUBA1C,SLMAP,MED30,TRAF4,STMN2,MAT2A |
| phospholipid binding | PLA2G7,BPIFC,SYT14,SPTB,ANXA9,BAIAP2L2,PAFAH2,ABCA1,LPAR3,SPTBN2 |
Interacting Protein
NSMAF has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NSMAF here. Most of them are supplied by our site. Hope this information will be useful for your research of NSMAF.
GABARAPL1;GABARAP;VASP;ACTB;MAP1LC3A;GABARAPL2;MAP1LC3C;MAP1LC3B;XIRP2;KRT4;TNFRSF1A
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