Recombinant Human NR2C2 protein, His & T7-tagged

• Cat.No.: NR2C2-1089H
• Product Overview: Recombinant Human NR2C2 aa. (Leu371~Leu596 (Accession # P49116) fused with N-terminal His & T7 tag was produced in E. coli cells.

Specification

• Species: Human
• Source: E.coli
• Tag: His&T7
• Protein Length: Leu371~Leu596
• Description: This gene encodes a protein that belongs to the nuclear hormone receptor family. Members of this family act as ligand-activated transcription factors and function in many biological processes such as development, cellular differentiation and homeostasis. The activated receptor/ligand complex is translocated to the nucleus where it binds to hormone response elements of target genes. The protein encoded by this gene plays a role in protecting cells from oxidative stress and damage induced by ionizing radiation. The lack of a similar gene in mouse results in growth retardation, severe spinal curvature, subfertility, premature aging, and prostatic intraepithelial neoplasia (PIN) development. Alternative splicing results in multiple transcript variants encoding different isoforms.
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 29.3kDa.
• Endotoxin: <1.0EU per 1µg (determined by the LAL method)
• Purity: >95%
• Characteristic: The isoelectric point is 5.2.
• Applications: SDS-PAGE; WB; ELISA; IP.
• Stability: The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage buffer: Supplied as lyophilized form in 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5% trehalose, and preservative.
• Reconstitution: Reconstitute in sterile ddH2O.

Gene Information

• Gene Name: NR2C2 nuclear receptor subfamily 2 group C member 2 [ Homo sapiens (human) ]
• Official Symbol: NR2C2
• Synonyms: NR2C2; nuclear receptor subfamily 2 group C member 2; TR4; TAK1; nuclear receptor subfamily 2 group C member 2; Nuclear hormone receptor TR4; orphan nuclear receptor TAK1; orphan nuclear receptor TR4; orphan receptor TR4; testicular nuclear receptor 4
• Gene ID: 7182
• mRNA Refseq: NM_001291694.1
• Protein Refseq: NP_001278623.1
• UniProt ID: P49116