NR2C2
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Official Full Name
NR2C2 nuclear receptor subfamily 2, group C, member 2 -
Overview
Members of the nuclear hormone receptor family, such as NR2C2, act as ligand-activated transcription factors. The;proteins have an N-terminal transactivation domain, a central DNA-binding domain with 2 zinc fingers, and a;ligand-binding domain at the C terminus. The activated receptor/ligand complex is translocated to the nucleus where it;binds to hormone response elements of target genes (Yoshikawa et al., 1996 (PubMed 8661150)). -
Synonyms
NR2C2;nuclear receptor subfamily 2, group C, member 2;TR4;nuclear receptor subfamily 2 group C member 2;hTAK1;TAK1;TR2R1;testicular receptor 4;orphan nuclear receptor TR4;Nuclear hormone receptor TR4;TR4 nuclear hormone receptor;orphan nuclear receptor TAK1;testicular nuclear receptor 4
Recombinant Proteins
- Mouse
- Human
- Rat
- Zebrafish
- Mammalian Cells
- E.coli
- HEK293
- Wheat Germ
- In Vitro Cell Free System
- His
- T7
- Non
- Avi
- Fc
- Flag
- DDK
- Myc
- GST
Involved Pathway
NR2C2 involved in several pathways and played different roles in them. We selected most pathways NR2C2 participated on our site, such as Androgen receptor signaling pathway,Gene Expression,Generic Transcription Pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NR2C2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Androgen receptor signaling pathway | CREBBP,SMAD3B,MYST2,RNF14,JUN,CTNNB2,RUNX2A,NCOA2,PARK7,ETV5A |
| TNF-alpha/NF-kB Signaling Pathway | MCC,NKIRAS1,PDCD2,LRPPRC,TXLNA,CAPN3,COPS3,PAPOLA,KPNA6,TNIP1 |
| Regulation of Androgen receptor activity | GATA2,TRIM24,SRY,SMARCE1,NR0B1,KAT7,NR2C1,SMARCA2,SPDEF,APPBP2 |
| Nuclear Receptors | NR2F1,NR1I3,NR4A2A,NR2F1A,NR2F2,NR2F6,NR2E1,RORAA,VDRB,NR1I2 |
| Nuclear Receptor transcription pathway | ESRRG,NR0B2A,ESR2B,NR6A1,NR2C2AP,NR2F6B,RXRBB,RORAA,RARAA,NR1I2 |
| Gene Expression | UHRF1,TSEN34,NR1H3,MTF2,ZNF74,SAP130,USP9,EIF4H,ELAC2,NRBP1 |
| Generic Transcription Pathway | ZNF324,ZIM3,ZNF747,NR1D2A,ZNF26,PPARAA,PRDX2,ZNF707,COX7C,CCNT2A |
Protein Function
NR2C2 has several biochemical functions, for example, protein binding,protein heterodimerization activity,receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NR2C2 itself. We selected most functions NR2C2 had, and list some proteins which have the same functions with NR2C2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| receptor activity | CADM4,TMEM123,IGF2R,Tnfrsf22,CADM1B,KLRB1F,NOTCH1A,TREML2,GRIN2BB,GRIN1A |
| steroid hormone receptor activity | NR1H5,ESR2B,PAQR7B,PAQR7,PPARAB,PPARG,ESR2A,ESRRG,NR4A1,NR0B2A |
| transcription coactivator activity | KAT6A,JUND,ENY2,FHL5,ATF6,SNW1,NEUROG3,SMARCA2,WWC1,MED17 |
| zinc ion binding | ADAMTS7,ADAM23,SUPT4H1,ZFYVE1,MAP3K1,MMP7,ADAMTS18,TRIM35-24,BRD1B,RBBP6 |
| protein binding | GPI1,YAP1,ZC3H18,G6PD,LDOC1,PLSCR3,SRF,BDKRB2,ACSS1,CCDC60 |
| sequence-specific DNA binding | MEF2A,PBX1B,DMRTA2,MKXA,IRX3,LEF1,POU3F3B,CEBPD,POU4F2,FOXO1A |
| protein heterodimerization activity | BRAF,KCNH1,BAXA,MAPK4,SIM1,IKZF4,PPP2R4,MYOG,APOA2,H2AFB2 |
| transcription factor activity, sequence-specific DNA binding | ZFP191,NEUROG1,ATF5,ESR2,SCAND3,HOXB2A,ZFP583,PURBA,TBX3A,GM239 |
Interacting Protein
NR2C2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NR2C2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NR2C2.
HSP90AB1;KDM1A;CD2AP;AIM2;PRPF40A;EED;S100A4;RPP38;SNW1;PYHIN1;Tab1;KLHL7;SMARCC1;PATZ1;TANC2;RBMX2
NR2C2 Related Signal Pathway
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