Recombinant Human NR2C2 Protein (Ile25-Pro579), His tagged

• Cat.No.: NR2C2-5145H
• Product Overview: Recombinant human NR2C2 (Ile25-Pro579) fused with His tag was expressed in E. coli.

Specification

• Description: Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear receptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences.
• Source: E. coli
• Species: Human
• Tag: His
• Form: Lyophilized powder/frozen liquid
• Molecular Mass: 50.68 kDa
• Protein length: Ile25-Pro579
• Purity: >90% as determined by SDS-PAGE.
• Notes: For research use only.
• Storage: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8 centigrade for one week. Store at -20 to -80 centigrade for twelve months from the date of receipt.
• Storage Buffer: Supplied as solution form in PBS, pH 7.5 or lyophilized from PBS, pH 7.5.
• Reconstitution: Reconstitute in sterile water for a stock solution.
• Shipping: They are shipped out with dry ice/blue ice unless customers require otherwise.

Gene Information

• Gene Name: NR2C2 nuclear receptor subfamily 2, group C, member 2 [ Homo sapiens (human) ]
• Official Symbol: NR2C2
• Synonyms: NR2C2; nuclear receptor subfamily 2, group C, member 2; TR4; nuclear receptor subfamily 2 group C member 2; hTAK1; TAK1; TR2R1; testicular receptor 4; orphan nuclear receptor TR4; Nuclear hormone receptor TR4; TR4 nuclear hormone receptor; orphan nuclear receptor TAK1; testicular nuclear receptor 4
• Gene ID: 7182
• mRNA Refseq: NM_003298
• Protein Refseq: NP_003289
• MIM: 601426
• UniProt ID: P49116