Recombinant Human NEIL2 Protein, MYC/DDK-tagged, C13 and N15-labeled
Cat.No. : | NEIL2-351H |
Product Overview : | NEIL2 MS Standard C13 and N15-labeled recombinant protein (NP_659480) with a C-terminal MYC/DDK tag, was expressed in HEK293 cells. |
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Species : | Human |
Source : | HEK293 |
Tag : | DDK&Myc |
Description : | This gene encodes a member of the Fpg/Nei family of DNA glycosylases. These glycosylases initiate the first step in base excision repair by cleaving oxidatively damaged bases and introducing a DNA strand break via their abasic site lyase activity. This enzyme is primarily associated with DNA repair during transcription and acts prefentially on cytosine-derived lesions, particularly 5-hydroxyuracil and 5-hydroxycytosine. It contains an N-terminal catalytic domain, a hinge region, and a C-terminal DNA-binding domain with helix-two-turn-helix and zinc finger motifs. This enzyme interacts with the X-ray cross complementing factor 1 scaffold protein as part of a multi-protein DNA repair complex. A pseudogene of this gene has been identified. [provided by RefSeq, Mar 2017] |
Molecular Mass : | 36.8 kDa |
AA Sequence : | MPEGPLVRKFHHLVSPFVGQQVVKTGGSSKKLQPASLQSLWLQDTQVHGKKLFLRFDLDEEMGPPGSSPTPEPPQKEVQKEGAADPKQVGEPSGQKTLDGSSRSAELVPQGEDDSEYLERDAPAGDAGRWLRVSFGLFGSVWVNDFSRAKKANKRGDWRDPSPRLVLHFGGGGFLAFYNCQLSWSSSPVVTPTCDILSEKFHRGQALEALGQAQPVCYTLLDQRYFSGLGNIIKNEALYRAGIHPLSLGSVLSASRREVLVDHVVEFSTAWLQGKFQGRPQHTQVYQKEQCPAGHQVMKEAFGPEDGLQRLTWWCPQCQPQLSEEPEQCQFSTRTRPLEQKLISEEDLAANDILDYKDDDDKV |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 3 months from receipt of products under proper storage and handling conditions. |
Storage : | Store at -80 centigrade. Avoid repeated freeze-thaw cycles. |
Concentration : | 50 μg/mL as determined by BCA |
Storage Buffer : | 100 mM glycine, 25 mM Tris-HCl, pH 7.3. |
Gene Name | NEIL2 nei endonuclease VIII-like 2 (E. coli) [ Homo sapiens (human) ] |
Official Symbol | NEIL2 |
Synonyms | NEIL2; nei endonuclease VIII-like 2 (E. coli); nei like 2 (E. coli); endonuclease 8-like 2; FLJ31644; MGC2832; MGC4505; NEH2; nei like 2; nei homolog 2; nei-like protein 2; endonuclease VIII-like 2; DNA glycosylase/AP lyase Neil2; DNA-(apurinic or apyrimidinic site) lyase Neil2; NEI2; |
Gene ID | 252969 |
mRNA Refseq | NM_145043 |
Protein Refseq | NP_659480 |
MIM | 608933 |
UniProt ID | Q969S2 |
◆ Recombinant Proteins | ||
NEIL2-2042H | Recombinant Human Nei Endonuclease VIII-like 2 (E. coli) | +Inquiry |
NEIL2 -1542H | Recombinant Human NEIL2 protein | +Inquiry |
Neil2-4366M | Recombinant Mouse Neil2 Protein, Myc/DDK-tagged | +Inquiry |
NEIL2-1963H | Recombinant Human Nei Endonuclease VIII-like 2 (E. coli), His-tagged | +Inquiry |
NEIL2-586H | Recombinant Human Nei Endonuclease VIII-like 2 (E. coli) | +Inquiry |
◆ Cell & Tissue Lysates | ||
NEIL2-3881HCL | Recombinant Human NEIL2 293 Cell Lysate | +Inquiry |
Not For Human Consumption!
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