NEIL2
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Official Full Name
nei endonuclease VIII-like 2 -
Overview
NEIL2 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate;the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA;strand break via the associated lyase reaction (Bandaru et al., 2002 (PubMed 12509226)). -
Synonyms
NEIL2;nei endonuclease VIII-like 2 (E. coli);nei like 2 (E. coli);endonuclease 8-like 2;FLJ31644;MGC2832;MGC4505;NEH2;nei like 2;nei homolog 2;nei-like protein 2;endonuclease VIII-like 2;DNA glycosylase/AP lyase Neil2;DNA-(apurinic or apyrimi
Recombinant Proteins
- Human
- Chicken
- Mouse
- E.coli
- Mammalian Cell
- HEK293
- HEK293T
- His
- Non
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NEIL2-3048H | Recombinant Human NEIL2 protein, His-tagged | E.coli | Human | His | 239 - 332 aa | |
| NEIL2 -1542H | Recombinant Human NEIL2 protein | E.coli | Human | Non |
|
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| NEIL2-15866H | Recombinant Human NEIL2, His-tagged | E.coli | Human | His | 1-332aa |
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| NEIL2-1963H | Recombinant Human Nei Endonuclease VIII-like 2 (E. coli), His-tagged | E.coli | Human | His |
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| NEIL2-2042H | Recombinant Human Nei Endonuclease VIII-like 2 (E. coli) | E.coli | Human | Non |
|
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| NEIL2-5185C | Recombinant Chicken NEIL2 | Mammalian Cell | Chicken | His |
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| NEIL2-586H | Recombinant Human Nei Endonuclease VIII-like 2 (E. coli) | E.coli | Human | Non |
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| NEIL2-3881HCL | Recombinant Human NEIL2 293 Cell Lysate | HEK293 | Human | Non |
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| NEIL2-351H | Recombinant Human NEIL2 Protein, MYC/DDK-tagged, C13 and N15-labeled | HEK293 | Human | Myc&DDK |
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| Neil2-4366M | Recombinant Mouse Neil2 Protein, Myc/DDK-tagged | HEK293T | Mouse | Myc&DDK |
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Involved Pathway
NEIL2 involved in several pathways and played different roles in them. We selected most pathways NEIL2 participated on our site, such as Base excision repair, which may be useful for your reference. Also, other proteins which involved in the same pathway with NEIL2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Base excision repair | MBD4,PARP2,NEIL1,UNGA,SMUG1,UNG,PARP1,xthA,PARP3,FEN1 |
Protein Function
NEIL2 has several biochemical functions, for example, DNA-(apurinic or apyrimidinic site) lyase activity,damaged DNA binding,hydrolase activity, hydrolyzing N-glycosyl compounds. Some of the functions are cooperated with other proteins, some of the functions could acted by NEIL2 itself. We selected most functions NEIL2 had, and list some proteins which have the same functions with NEIL2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| hydrolase activity, hydrolyzing N-glycosyl compounds | MAN2A1,UNGA,TDG.1,MAN2A2 |
| zinc ion binding | NPLOC4,ZNF385C,ZNF8,TRIM27,TRIM24,LNPEP,RNF6,MMP17,NUP153,NANOS3 |
| damaged DNA binding | CRY-DASH,RPA2,RAD1,MPG,MGMT,RBBP8,NEIL3,ERCC4,UNG,TRP53 |
| microtubule binding | CHP1,KATNAL1,KIF2A,DCX,KIF20B,SPAG8,NEFM,KIF5C,MAP1S,FGF13 |
| DNA-(apurinic or apyrimidinic site) lyase activity | HMGA1-RS1,HMGA1A,APLF,APEX2,RPS3,ALKBH1,HMGA1B,NEIL1,NTHL1,HMGA2 |
| protein binding | MRPL12,ANAPC4,TBC1D16,TEX10,ABCD1,AKTIP,ZBTB49,RHOV,TTF2,CLOCKB |
Interacting Protein
NEIL2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEIL2 here. Most of them are supplied by our site. Hope this information will be useful for your research of NEIL2.
TRIM27;MEOX1;REL
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