Recombinant Human Nei Endonuclease VIII-like 2 (E. coli)

Cat.No. : NEIL2-586H
Product Overview : Recombinant human NEIL2 was expressed in and purified fromE. coli.
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Species : Human
Source : E.coli
Tag : Non
Description : NEIL2 is a DNA glycosylase involved in base excision repair of oxidative DNA damage. It is a member of the Fpg/Nei/NEIL family of bi-functional DNA glycosylases. Following its glycosylase action, NEIL2 catalyzes sequential β-elimination and δ-elimination reactions via its associated AP lyase. This results in a one-nucleotide gap in DNA containing a 3' phosphate group. A phosphatase is needed to remove the 3'phosphate group before DNA repair synthesis can occur.
Purity : Apparent homogeneity by SDS-PAGE and Coomassie blue staining.
Formulation : 20 mM Tris-HCl, pH 7.5, 300 mM NaCl, 10% glycerol.
Storage : Store at -70°C. Aliquot to avoid repeated freezing and thawing.
Gene Name NEIL2 nei endonuclease VIII-like 2 (E. coli) [ Homo sapiens ]
Synonyms NEIL2; nei endonuclease VIII-like 2 (E. coli); NEH2; NEI2; MGC2832; MGC4505; FLJ31644; nei like 2; EC 4.2.99.18; DNA glycosylase/AP lyase Neil2; DNA-(apurinic or apyrimidinic site) lyase Neil2; Nei-like protein 2; Nei homolog 2; Nei-like 2
Gene ID 252969
mRNA Refseq NM_001135746
Protein Refseq NP_001129218
MIM 608933
UniProt ID Q969S2
Chromosome Location 8p23.1
Pathway Base excision repair
Function DNA-(apurinic or apyrimidinic site) lyase activity; damaged DNA binding; hydrolase activity, hydrolyzing N-glycosyl compounds; lyase activity; metal ion binding; microtubule binding; zinc ion binding

Not For Human Consumption!

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