Recombinant Human Nei Endonuclease VIII-like 2 (E. coli)

• Cat.No.: NEIL2-586H
• Product Overview: Recombinant human NEIL2 was expressed in and purified fromE. coli.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Description: NEIL2 is a DNA glycosylase involved in base excision repair of oxidative DNA damage. It is a member of the Fpg/Nei/NEIL family of bi-functional DNA glycosylases. Following its glycosylase action, NEIL2 catalyzes sequential β-elimination and δ-elimination reactions via its associated AP lyase. This results in a one-nucleotide gap in DNA containing a 3' phosphate group. A phosphatase is needed to remove the 3'phosphate group before DNA repair synthesis can occur.
• Purity: Apparent homogeneity by SDS-PAGE and Coomassie blue staining.
• Formulation: 20 mM Tris-HCl, pH 7.5, 300 mM NaCl, 10% glycerol.
• Storage: Store at -70°C. Aliquot to avoid repeated freezing and thawing.

Gene Information

• Gene Name: NEIL2 nei endonuclease VIII-like 2 (E. coli) [ Homo sapiens ]
• Synonyms: NEIL2; nei endonuclease VIII-like 2 (E. coli); NEH2; NEI2; MGC2832; MGC4505; FLJ31644; nei like 2; EC 4.2.99.18; DNA glycosylase/AP lyase Neil2; DNA-(apurinic or apyrimidinic site) lyase Neil2; Nei-like protein 2; Nei homolog 2; Nei-like 2
• Gene ID: 252969
• mRNA Refseq: NM_001135746
• Protein Refseq: NP_001129218
• MIM: 608933
• UniProt ID: Q969S2
• Chromosome Location: 8p23.1
• Pathway: Base excision repair
• Function: DNA-(apurinic or apyrimidinic site) lyase activity; damaged DNA binding; hydrolase activity, hydrolyzing N-glycosyl compounds; lyase activity; metal ion binding; microtubule binding; zinc ion binding