Recombinant Human N-acetyltransferase 6, His-tagged

• Cat.No.: NAT6-132H
• Product Overview: Recombinant human N-acetyltransferase 6 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography, 35.9 kDa (328aa)(Real molecular weight on SDS-PAGE will be shift up).

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Description: N-acetyltransferase, also known as FUS2 (NAT6), is an enzyme that catalyzes the transfer of acetyl groups from acetyl-CoA to acrylamines. This enzyme is physically localized in the cytoplasm and its activity has been documented by its feasibility to acetylate the N-terminus of proteins using a ping-pong-like mechanism and by its substrate specificity. Since the Fus-2 gene maps to the chromosomal region 3p21.3, which contains at least one tumor suppressor gene, the N-acetyltransferase functions of Fus-2 may be relevant to its potential role in cancer.
• Sequences of amino acids: MGSSHHHHHH SSGLVPRGSH MQELTLSPGP AKLTPTLDPT HRMELILSTS PAELTLDPAC QPKLPLDSTC QPEMTFNPGP TELTLDPEHQ PEETPAPSLA ELTLEPVHRR PELLDACADL INDQWPRSRT SRLHSLGQSS DAFPLCLMLL SPHPTLEAAP VVVGHARLSR VLNQPQSLLV ETVVVARALR GRGFGRRLME GLEVFARARG FRKLHLTTHD QVHFYTHLGY QLGEPVQGLV FTSRRLPATL LNAFPTAPSP RPPRKAPNLT AQAAPRGPKG PPLPPPPPLP ECLTISPPVP SGPPSKSLLE TQYQNVRGRP IFWMEKDI
• Formulation: Liquid. In 20 mM Tris-HCl buffer (pH 8.0) containing 100 mM NaCl 20% glycerol.
• Purity: > 95% by SDS - PAGE
• Concentration: 0.5 mg/ml (determined by Bradford assay)
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: NAT6 N-acetyltransferase 6 (GCN5-related) [ Homo sapiens ]
• Synonyms: EC 2.3.1.-; FUS-2; FUS2; N-acetyltransferase 6; N-acetyltransferase 6 (GCN5-related); Protein fus-2; Protein fusion-2; putative tumor suppressor; NAT6
• Gene ID: 24142
• mRNA Refseq: NM_012191
• Protein Refseq: NP_036323
• MIM: 607073
• UniProt ID: Q93015
• Chromosome Location: 3p21.3
• Pathway: 1- and 2-Methylnaphthalene degradation; Alkaloid biosynthesis II; Benzoate degradation via CoA ligation; Ethylbenzene degradation; Glycerophospholipid metabolism; Limonene and pinene degradation; Phenylalanine metabolism; Tyrosine metabolism
• Function: N-acetyltransferase activity; acyltransferase activity; transferase activity