Recombinant Human MTHFS Protein, Myc/DDK-tagged

• Cat.No.: MTHFS-01H
• Product Overview: Recombinant protein of human 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) (MTHFS) with C-terminal Myc/DDK tag, expressed in HEK293T.

Specification

• Species: Human
• Source: HEK293
• Tag: Myc&DDK
• Description: The protein encoded by this gene is an enzyme that catalyzes the conversion of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate, a precursor of reduced folates involved in 1-carbon metabolism. An increased activity of the encoded protein can result in an increased folate turnover rate and folate depletion. Three transcript variants encoding two different isoforms have been found for this gene.
• Molecular Mass: 23.1 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol

Gene Information

• Gene Name: MTHFS methenyltetrahydrofolate synthetase [ Homo sapiens (human) ]
• Official Symbol: MTHFS
• Synonyms: MTHFS; methenyltetrahydrofolate synthetase; NEDMEHM; HsT19268; 5-formyltetrahydrofolate cyclo-ligase; 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase); methenyl-THF synthetase; EC 6.3.3.2
• Gene ID: 10588
• mRNA Refseq: NM_006441
• Protein Refseq: NP_006432
• MIM: 604197
• UniProt ID: P49914