MTHFS
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Official Full Name
5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) -
Overview
The protein encoded by this gene is an enzyme that catalyzes the conversion of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate, a precursor of reduced folates involved in 1-carbon metabolism. An increased activity of the encoded protein can result in an increased folate turnover rate and folate depletion. Three transcript variants encoding two different isoforms have been found for this gene. -
Synonyms
MTHFS;5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase);5-formyltetrahydrofolate cyclo-ligase;HsT19268;10-methenyl-tetrahydrofolate synthetase;5;5 formyltetrahydrofolate cyclo ligase;5,10 methenyl tetrahydrofolate synthetase;FLJ30410;Methenyl THF synthetase;Methenyl-THF synthetase;MTHFS_HUMAN;OTTHUMP00000185568
Recombinant Proteins
- Mouse
- Rhesus macaque
- Human
- Chicken
- Mammalian Cells
- E.coli
- HEK293
- Wheat Germ
- His
- Non
- Myc&DDK
- His&Fc&Avi
- His&SUMO
- GST
Involved Pathway
MTHFS involved in several pathways and played different roles in them. We selected most pathways MTHFS participated on our site, such as Metabolic pathways,One Carbon Metabolism,One carbon pool by folate, which may be useful for your reference. Also, other proteins which involved in the same pathway with MTHFS were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| One carbon pool by folate | MTHFD1,MTFMT,ST20-MTHFS,MTR,ALDH1L2,SHMT2,GART,MTHFD2L,TYMS,MTHFR |
| One Carbon Metabolism | ST20-MTHFS,AHCY,MTFMT,MTHFD2,ALDH1L1,FTCD |
| Metabolic pathways | GLSA,ATP6V0E1,PYGM,ATP6V1F,PAFAH1B1B,GPAT2,TKTB,AGXTB,ASAH2,G6PC |
Protein Function
MTHFS has several biochemical functions, for example, 5-formyltetrahydrofolate cyclo-ligase activity,ATP binding,folic acid binding. Some of the functions are cooperated with other proteins, some of the functions could acted by MTHFS itself. We selected most functions MTHFS had, and list some proteins which have the same functions with MTHFS. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | KIT,NLRP3,CLK1,SUPV3L1,ORC4L,DDX27,XRCC2,PARS2,PLK2,DCLK2 |
| folic acid binding | FTCD,DAAM2,DHFR,TYMS,FOLR1,FOLR3,SLC46A1,SLC19A1,DMGDH,FOLR2 |
| metal ion binding | DZIP1,TNNI3K,CYP4T8,CNOT6,PLD6,ZNF729,SAR1B,NR5A1A,FCER2,GTF3AB |
Interacting Protein
MTHFS has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MTHFS here. Most of them are supplied by our site. Hope this information will be useful for your research of MTHFS.
TSC22D4
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